H9人T淋巴瘤白血病细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1055

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameH9
SynonymsHT clone H9; HT(H9); H 9; H-9
AccessionBTCC-1055
Resource Identification InitiativeTo cite this cell line use: H9 (BTCC-1055)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Virology: Permissive for HIV-1 replication. Is accordingly used to isolate and propagate HIV-1 from the blood of patients with AIDS.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
Discontinued: IZSLER; BS TCL 19; probable.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestrySource: PubMed=30894373

Origin% genome


African4.91
Native American1.41
East Asian, North5.59
East Asian, South0
South Asian0
European, North61.37
European, South26.72
DiseaseSezary syndrome (NCIt: C3366)
Sezary syndrome (ORDO: Orphanet_3162)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0337 (HuT 78)
Children:



CVCL_X680 (H9/HIV-2MVP-11971)CVCL_X681 (H9/HIV-2MVP-15132)CVCL_3514 (H9/HTLV-IIIB)
CVCL_X621 (H9/HTLV-IIICC)CVCL_X620 (H9/HTLV-IIIMN)CVCL_X619 (H9/HTLV-IIIRF)
CVCL_X610 (H9/SIVmac186)CVCL_D536 (H938)CVCL_U264 (RH9)
Sex of cellMale
Age at sampling53Y
CategoryCancer cell line
STR profileSource(s): ATCC; CLS; Cosmic-CLP; ECACC; KCLB

Markers:
AmelogeninX,Y
CSF1PO11
D2S133820,25
D3S135815,16
D5S81811
D6S104312
D7S8208,11
D8S117912,14
D12S39118,23
D13S3178,12
D16S53911,12
D18S5118
D19S43314
D21S1130
FGA21,25
Penta D9
Penta E13,15
TH018,9
TPOX8,9
vWA14,15

Run an STR similarity search on this cell line
Web pageshttp://www.nibsc.org/Default.aspx?pageid=597&id=0001&theme=default
http://www.bmj.com/rapid-response/2011/10/30/cell-lines-hut102-and-hut78
Publications

PubMed=6151082; DOI=10.1016/s0140-6736(84)91666-0
Popovic M., Read-Connole E., Gallo R.C.
T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III.
Lancet 324:1472-1473(1984)

PubMed=2567177; DOI=10.1089/aid.1989.5.253
Mann D.L., O'Brien S.J., Gilbert D.A., Reid Y.A., Popovic M., Read-Connole E., Gallo R.C., Gazdar A.F.
Origin of the HIV-susceptible human CD4+ cell line H9.
AIDS Res. Hum. Retroviruses 5:253-255(1989)

PubMed=2193399; DOI=10.1126/science.2193399
Rubinstein E.
The untold story of HUT78.
Science 248:1499-1507(1990)

PubMed=1460674; DOI=10.1093/jnci/84.24.1922
Chen T.-R.
Karyotypic derivation of H9 cell line expressing human immunodeficiency virus susceptibility.
J. Natl. Cancer Inst. 84:1922-1926(1992)

PubMed=8320746; DOI=10.1093/jnci/85.14.1168
Bunn P.A. Jr., Whang-Peng J., Gazdar A.F., Minna J.D., Carney D.N.
Karyotypic derivation of H9 cell line.
J. Natl. Cancer Inst. 85:1168-1169(1993)

PubMed=8127147
Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Borgonovo-Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0003581
CLO; CLO_0003612
CLDB; cl1556
CLDB; cl1557
CLDB; cl7167
CCRID; 4201MOU-CCTCC00031
Cell_Model_Passport; SIDM01251
Cosmic-CLP; 907043
DepMap; ACH-002240
LINCS_LDP; LCL-1144
Lonza; 910
TOKU-E; 3613
Anatomy/cell type resourcesBTO; BTO:0001944
Biological sample resourcesBioSample; SAMN03472731
Cell line collections (Providers)ATCC; HTB-176
CCTCC; GDC0031
CLS; 300460
ECACC; 85050301
HIVReagentProgram; ARP-87
ICLC; HTL05006
IZSLER; BS TCL 19
KCB; KCB 200418YJ
KCLB; 30176
Chemistry resourcesChEMBL-Cells; CHEMBL3308402
ChEMBL-Targets; CHEMBL614806
GDSC; 907043
PharmacoDB; H9_439_2019
PubChem_Cell_line; CVCL_1240
Encyclopedic resourcesWikidata; Q54872230
Experimental variables resourcesEFO; EFO_0003045
Gene expression databasesArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669836
Polymorphism and mutation databasesCosmic; 687842
Cosmic; 907043
Cosmic; 933542
Cosmic; 2301568
Cosmic; 2668295
IARC_TP53; 21356
Proteomic databasesPRIDE; PXD030304

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