HCMEC/D3永生化人脑微血管内皮细胞

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1059

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line namehCMEC/D3
SynonymsHCMEC/D3; CMEC/D3; human Cortical Microvessels Endothelial Cells/D3
AccessionBTCC-1059
Resource Identification InitiativeTo cite this cell line use: hCMEC/D3 (BTCC-1059)
CommentsGroup: Patented cell line.
Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-3308.
Transfected with: HGNC; 11730; TERT.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Deep quantitative membrane proteome analysis.
Omics: Secretome proteome analysis.
Derived from site: In situ; Brain, temporal lobe, blood microvessel; UBERON=UBERON_0001871+UBERON_8410081.
Cell type: Endothelial cell; CL=CL_0000115.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellFemale
Age at samplingAdult
CategoryTransformed cell line
STR profileSource(s): CCRID; Genomics_Center_BCF_Technion; Millipore

Markers:
AmelogeninX
CSF1PO10,12
D1S165615.3,17.3
D2S44113
D2S133816,20
D3S135816,17
D5S81811
D7S82010,12
D8S117915,16
D10S124814,15
D12S39119.3,22
D13S31711,14
D16S5399,12
D18S5112,19
D21S1130,32.2
D22S104511,15
FGA22,26
Penta D10,12
Penta E5,10
TH017,9
TPOX10,11
vWA14,17

Run an STR similarity search on this cell line
Web pageshttps://www.cedarlanelabs.com/Products/Detail/CLU512?lob=Cellutions
https://cornell.flintbox.com/technologies/bc9b2b68-4f6b-4071-bece-64241c21e438
Publications

PubMed=16141364; DOI=10.1096/fj.04-3458fje
Weksler B.B., Subileau E.-A., Perriere N., Charneau P., Holloway K., Leveque M., Tricoire-Leignel H., Nicotra A., Bourdoulous S., Turowski P., Male D.K., Roux F., Greenwood J., Romero I.A., Couraud P.-O.
Blood-brain barrier-specific properties of a human adult brain endothelial cell line.
FASEB J. 19:1872-1874(2005)

Patent=US8084254
Couraud P.-O., Romero I.A., Weksler B.B.
Human blood brain barrier model.
Patent number US8084254, 27-Dec-2011

PubMed=23531482; DOI=10.1186/2045-8118-10-16
Weksler B.B., Romero I.A., Couraud P.-O.
The hCMEC/D3 cell line as a model of the human blood brain barrier.
Fluids Barriers CNS 10:16.1-16.10(2013)

PubMed=26718731; DOI=10.1016/j.jprot.2015.12.011
Llombart V., Garcia-Berrocoso T., Bech-Serra J.J., Simats A., Bustamante A., Giralt D., Reverter-Branchat G., Canals F., Hernandez-Guillamon M., Montaner J.
Characterization of secretomes from a human blood brain barrier endothelial cells in-vitro model after ischemia by stable isotope labeling with aminoacids in cell culture (SILAC).
J. Proteomics 133:100-112(2016)

PubMed=30983357; DOI=10.1021/acs.molpharmaceut.9b00114
Masuda T., Hoshiyama T., Uemura T., Hirayama-Kurogi M., Ogata S., Furukawa A., Couraud P.-O., Furihata T., Ito S., Ohtsuki S.
Large-scale quantitative comparison of plasma transmembrane proteins between two human blood-brain barrier model cell lines, hCMEC/D3 and HBMEC/cibeta.
Mol. Pharm. 16:2162-2171(2019)

Cross-references
Cell line databases/resourcesCCRID; 5301HUM-KCB19022YJ
Anatomy/cell type resourcesBTO; BTO:0003339
Cell line collections (Providers)BCRJ; 0401
KCB; KCB 2019022YJ
Millipore; SCC066
Chemistry resourcesChEMBL-Cells; CHEMBL4513105
PubChem_Cell_line; CVCL_U985
Encyclopedic resourcesWikidata; Q54881892
Proteomic databasesPRIDE; PXD002292

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