HepG2.2.15表达HBV病毒的人肝癌细胞

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1068

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameHep-G2/2.2.15
SynonymsHEP-G2/2.2.15; Hep-G2/2215; HepG2/2215; HepG2-2.2.15; HepG2 2.2.15; HepG2.2.15; HepG2(2.2.15); 2.2.15
AccessionBTCC-1068
Resource Identification InitiativeTo cite this cell line use: Hep-G2/2.2.15 (BTCC-1068)
CommentsPopulation: Caucasian.
Virology: Contains 2 head to tails stably integrated hepatitis B virus (HBV) of the D-genotype.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
DiseaseHepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0027 (Hep-G2)
Sex of cellMale
Age at sampling15Y
CategoryCancer cell line
STR profileSource(s): Millipore

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135815,16
D5S81811,12
D7S82010
D8S117915,16
D13S3179,13
D16S53912,13
D18S5113,14
D21S1129,31
FGA22,25
Penta D9,13
Penta E15,20
TH019
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3029758; DOI=10.1073/pnas.84.4.1005
Sells M.A., Chen M.L., Acs G.
Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.
Proc. Natl. Acad. Sci. U.S.A. 84:1005-1009(1987)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E., Ponchel F., Yakicier C., Ji J.-W., Ozturk M.
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=21448419; DOI=10.3748/wjg.v17.i9.1152
Zhao R., Wang T.-Z., Kong D., Zhang L., Meng H.-X., Jiang Y., Wu Y.-Q., Yu Z.-X., Jin X.-M.
Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2.
World J. Gastroenterol. 17:1152-1159(2011)

PubMed=29481805; DOI=10.1016/j.bbrc.2018.02.175
Ogura N., Ogawa K., Watashi K., Ito T., Wakita T.
Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line.
Biochem. Biophys. Res. Commun. 498:64-71(2018)

Cross-references
Cell line databases/resourcesCLO; CLO_0001176
CLDB; cl33
Anatomy/cell type resourcesBTO; BTO:0005621
Cell line collections (Providers)CCTCC; GDC0141
Millipore; SCC249
Chemistry resourcesChEMBL-Cells; CHEMBL3833241
ChEMBL-Targets; CHEMBL4296438
PubChem_Cell_line; CVCL_L855
Encyclopedic resourcesWikidata; Q54882787
Polymorphism and mutation databasesCosmic; 979733

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