HK-2人肾皮质近曲小管上皮细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1071

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameHK-2 [Human kidney]
SynonymsHk-2; HK2; Human Kidney-2
AccessionBTCC-1071
Resource Identification InitiativeTo cite this cell line use: HK-2 [Human kidney] (BTCC-1071)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [pLXSN16E6E7].
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Genome ancestrySource: PubMed=30894373

Origin% genome


African3.63
Native American0
East Asian, North3.68
East Asian, South0
South Asian0
European, North62.77
European, South29.92
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:


CVCL_UC05 (HK-2-KIM-1)CVCL_WZ51 (HKC)
Sex of cellMale
Age at samplingAdult
CategoryTransformed cell line
STR profileSource(s): AddexBio; ATCC; CCRID; KCLB

Markers:
AmelogeninX (CCRID)
X,Y (AddexBio; ATCC; KCLB)
CSF1PO13
D2S133817,25
D3S135816,17
D5S81812
D7S82010,11
D8S117910,14
D13S3179
D16S53911,12
D18S5112
D19S43315,15.2
D21S1128,30
FGA20,22
TH019
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=8127021; DOI=10.1038/ki.1994.6
Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B.
HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney.
Kidney Int. 45:48-57(1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20555413; DOI=10.1139/y10-023
Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.
Can. J. Physiol. Pharmacol. 88:448-455(2010)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33122286; DOI=10.1681/ASN.2020010009
Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references
Cell line databases/resourcesCLO; CLO_0003771
MCCL; MCC:0000193
CCRID; 3101HUMSCSP511
CCRID; 4201HUM-CCTCC00152
Cell_Model_Passport; SIDM01818
DepMap; ACH-001087
Lonza; 769
Anatomy/cell type resourcesBTO; BTO:0003575
Biological sample resourcesBioSample; SAMN03472562
ENCODE; ENCBS188NWH
Cell line collections (Providers)AddexBio; T0011004/4929
ATCC; CRL-2190
BCRC; 60097
CCTCC; GDC0152
CLS; 305021
KCB; KCB 200815YJ
KCLB; 22190
Chemistry resourcesChEMBL-Cells; CHEMBL4295396
ChEMBL-Targets; CHEMBL4296428
PharmacoDB; HK2_545_2019
PubChem_Cell_line; CVCL_0302

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