HL-60人原髓细胞白血病细胞

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1072

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameHL-60
SynonymsHL 60; HL.60 HL60; Human Leukemia-60
AccessionBTCC-1072
Resource Identification InitiativeTo cite this cell line use: HL-60 (BTCC-1072)
CommentsGroup: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
Registration: National Institute of Standards and Technology, Standard Reference Materials; SRM 2392-I.
Population: Caucasian.
Biotechnology: Used a source of mitochondrial DNA for USA forensic testing.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 16 hours (PubMed=8343448); 28 hours (PubMed=25984343); ~40 hours (DSMZ=ACC-3).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; PubMed=12661003; Sanger).
Omics: Array-based CGH.
Omics: Cell surface proteome.
Omics: CTCF ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: CNV analysis.
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Mitochondrial genome sequenced.
Omics: N-glycan profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Anecdotal: Established at the 60th attempt to culture human leukemia biopsies in Gallo's lab. All the preceding attempts having failed.
Misspelling: IIL-60; Note=Occasionally.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (PubMed=2858093).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (PubMed=17088437; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (PubMed=12068308; PubMed=17088437; Cosmic-CLP; DepMap).
HLA typingSource: PubMed=26589293
Class I
HLA-AA*01:01,24:15
HLA-BB*57:01,57:01
HLA-CC*06:02,06:02

Source: DSMZCellDive=ACC-3
Class I
HLA-BB*57:01:01,57:01:01
HLA-CC*06:02:01,06:02:01
Genome ancestrySource: PubMed=30894373

Origin% genome


African1.15
Native American0.42
East Asian, North0.4
East Asian, South0
South Asian0
European, North71.71
European, South26.32
DiseaseAdult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_2892 (Eos-HL-60)CVCL_8439 (HIMeg-1)CVCL_UM46 (HL-60 248)
CVCL_VK43 (HL-60 blast)CVCL_2493 (HL-60 clone 15)CVCL_B6DR (HL-60 clone F8)
CVCL_B6DS (HL-60 clone H6)CVCL_WZ17 (HL-60 DeltaF508-CF)CVCL_UM47 (HL-60 SCX3)
CVCL_UM48 (HL-60 SN3)CVCL_A794 (HL-60(TB))CVCL_A4BY (HL-60-Luc2)
CVCL_4635 (HL-60-R2)CVCL_WW75 (HL-60-Y3)CVCL_YP33 (HL-60/5FU)
CVCL_0304 (HL-60/ADR)CVCL_IP18 (HL-60/AMSA)CVCL_WR44 (HL-60/AR)
CVCL_4V19 (HL-60/ara-C [Japan 2011])CVCL_Z938 (HL-60/ara-C [USA 1984])CVCL_C3M3 (HL-60/CDDP)
CVCL_4458 (HL-60/DNR)CVCL_3332 (HL-60/MX1)CVCL_II78 (HL-60/R3)
CVCL_XE38 (HL-60/RS)CVCL_II77 (HL-60/S4)CVCL_0305 (HL-60/VCR)
CVCL_4967 (HL-60/Vinc)CVCL_YT56 (HL-60R)CVCL_RS49 (HL-60rARA-C2mug/ML)
CVCL_4V55 (HL/CAFdA20)CVCL_AR88 (HL60 Ast.1)CVCL_AR85 (HL60 Ast.25)
CVCL_2495 (HL60 Ast.3)CVCL_2496 (HL60 Ast.4)CVCL_2497 (HL60 M2)
CVCL_2498 (HL60 M4)CVCL_AR89 (HL60 Sp1)CVCL_2944 (HL60(S))
CVCL_C1LK (HL60-CDR)CVCL_WI27 (HL60/AR)CVCL_A0ST (HL60/MRI)
CVCL_2945 (HL60RG)CVCL_8710 (HP100-1)CVCL_8711 (HP50-2)
CVCL_YN03 (NDi001-A)CVCL_D567 (OM10.1)CVCL_0478 (P39)
CVCL_2162 (PLB-985)CVCL_8907 (RED-3)CVCL_J128 (VXG3)
CVCL_J129 (XQH)CVCL_8931 (YJ)
Sex of cellFemale
Age at sampling36Y
CategoryCancer cell line
STR profileSource(s): AddexBio; ATCC; CCRID; CLS; COG; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO13,14
D2S133817
D3S135816
D5S81812
D7S82011,12
D8S117912 (DSMZ)
12,13 (CCRID; PubMed=11416159; PubMed=25877200)
13 (CLS)
D13S3178,11
D16S53911
D18S5114 (CLS)
14,15 (CCRID; DSMZ; PubMed=11416159; PubMed=25877200)
D19S43314
D21S1129,30 (CCRID; COG; DSMZ; PubMed=25877200)
30 (CLS; PubMed=11416159)
FGA22,24
Penta D10,11 (DSMZ)
10,12 (CLS; PubMed=25877200)
Penta E13 (CLS)
13,14 (DSMZ; PubMed=25877200)
TH017,8 (AddexBio; ATCC; CCRID; CLS; COG; Cosmic-CLP; DSMZ; KCLB; PubMed=11416159; PubMed=25877200; RCB; TKG)
8 (ECACC; JCRB)
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pageshttps://en.wikipedia.org/wiki/HL60
https://www.phe-culturecollections.org.uk/media/154986/hl60-cell-line-profile.pdf
http://www.cells-talk.com/index.php/page/copelibrary?key=HL-60
https://strap.nci.nih.gov/celline_detail.php?sample_id=32
http://genome.ucsc.edu/ENCODE/protocols/cell/human/HL-60_Stam_protocol.pdf
https://www.proteinatlas.org/learn/cellines
https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-132.html
https://tcpaportal.org/mclp/
Publications

PubMed=271272; DOI=10.1038/270347a0
Collins S.J., Gallo R.C., Gallagher R.E.
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.
Nature 270:347-349(1977)

PubMed=288488; DOI=10.1182/blood.V54.3.713.713
Gallagher R.E., Collins S.J., Trujillo J.M., McCredie K., Ahearn M.J., Tsai S., Metzgar R., Aulakh G., Ting R., Ruscetti F.W., Gallo R.C.
Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia.
Blood 54:713-733(1979)

PubMed=6996765; DOI=10.1182/blood.V56.3.344.344
Koeffler H.P., Golde D.W.
Human myeloid leukemia cell lines: a review.
Blood 56:344-350(1980)

PubMed=6255959; DOI=10.1016/0014-4827(81)90422-5
Olsson I., Olofsson T.
Induction of differentiation in a human promyelocytic leukemic cell line (HL-60). Production of granule proteins.
Exp. Cell Res. 131:225-230(1981)

PubMed=6945469; DOI=10.1016/0145-2126(81)90018-7
Major P.P., Griffin J.D., Minden M., Kufe D.W.
A blast subclone of the HL-60 human promyelocytic cell line.
Leuk. Res. 5:429-430(1981)

PubMed=6954533; DOI=10.1073/pnas.79.7.2194
Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., Aaronson S.A., Wong-Staal F.
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G.
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2858093; DOI=10.1073/pnas.82.3.790
Wolf D., Rotter V.
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.
Proc. Natl. Acad. Sci. U.S.A. 82:790-794(1985)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3860286
Bhalla K., Hindenburg A.A., Taub R.N., Grant S.
Isolation and characterization of an anthracycline-resistant human leukemic cell line.
Cancer Res. 45:3657-3662(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3311197; DOI=10.1182/blood.V70.5.1233.1233
Collins S.J.
The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.
Blood 70:1233-1244(1987)

DOI=10.1159/000415060
Morikawa S., Harada T., Katoh T.
Heterogeneity of cellular origins in human malignant lymphoma cell line derived from histo-monocytic lineage cells.
(In) Cellular, molecular, genetic approaches to immunodiagnosis and immunotherapy. 8th International conference on labeled antibodies, Tokyo, November 1985; Kano K., Mori S., Sugisaki T., Torisu M. (eds.); pp.373-380; Karger; Basel (1988)

PubMed=3335022
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3422031; DOI=10.1182/blood.V71.1.242.242
Dalton W.T. Jr., Ahearn M.J., McCredie K.B., Freireich E.J., Stass S.A., Trujillo J.M.
HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3.
Blood 71:242-247(1988)

PubMed=2545346
Hindenburg A.A., Gervasoni J.E. Jr., Krishna S., Stewart V.J., Rosado M., Lutzky J., Bhalla K., Baker M.A., Taub R.N.
Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.
Cancer Res. 49:4607-4614(1989)

PubMed=1970118; DOI=10.1128/mcb.10.5.2154-2163.1990
Collins S.J., Robertson K.A., Mueller L.
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).
Mol. Cell. Biol. 10:2154-2163(1990)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Nakano A., Harada T., Morikawa S., Kato Y.
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1368402; DOI=10.1007/BF02540028
Schumpp B., Schlaeger E.-J.
Growth study of lactate and ammonia double-resistant clones of HL-60 cells.
Cytotechnology 8:39-44(1992)

PubMed=1574572; DOI=10.2307/3578273
Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8316623; DOI=10.2307/3578190
Evans H.H., Ricanati M., Horng M.-F., Jiang Q.-Y., Mencl J., Olive P.L.
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
Radiat. Res. 134:307-315(1993)

PubMed=8343448
Kajigaya Y., Sasaki H., Ikuta K., Matsuyama S., Hirabayashi Y., Inoue T.
Serum-free culture for leukemia cells.
Hum. Cell 6:49-56(1993)

PubMed=7630190
Zhou M., Gu L., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=8562479
Banerjee D., Lenz H.-J., Schnieders B., Manno D.J., Ju J.-F., Spears C.P., Hochhauser D., Danenberg K.D., Danenberg P.V., Bertino J.R.
Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.
Cell Growth Differ. 6:1405-1413(1995)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9434637; DOI=10.1006/excr.1997.3813
Piepmeier E.H., Kalns J.E., McIntyre K.M., Lewis M.L.
Prolonged weightlessness affects promyelocytic multidrug resistance.
Exp. Cell Res. 237:410-418(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9557624; DOI=10.1038/sj.leu.2400976
Mattii L., Barale R., Petrini M.
Use of the comet test in the evaluation of multidrug resistance of human cell lines.
Leukemia 12:627-632(1998)

PubMed=9607592
Ju J.-F., Banerjee D., Lenz H.-J., Danenberg K.D., Schmittgen T.C., Spears C.P., Schonthal A.H., Manno D.J., Hochhauser D., Bertino J.R., Danenberg P.V.
Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.
Clin. Cancer Res. 4:1315-1322(1998)

PubMed=9737686; DOI=10.1038/sj.leu.2401112
Zhang W., Ohnishi K., Shigeno K., Fujisawa S., Naito K., Nakamura S., Takeshita K., Takeshita A., Ohno R.
The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
Leukemia 12:1383-1391(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000),255-262.
Leuk. Res. 25:275-278(2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12661003; DOI=10.1002/gcc.10196
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.-F., Schlag P.M., Scherneck S.
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=16120335; DOI=10.1016/S1567-7249(03)00010-2
Levin B.C., Holland K.A., Hancock D.K., Coble M., Parsons T.J., Kienker L.J., Williams D.W., Jones M., Richie K.L.
Comparison of the complete mtDNA genome sequences of human cell lines-- HL-60 and GM10742A -- from individuals with pro-myelocytic leukemia and Leber hereditary optic neuropathy, respectively, and the inclusion of HL-60 in the NIST human mitochondrial DNA standard reference material -- SRM 2392-I.
Mitochondrion 2:387-400(2003)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433
Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A.P., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Mironenko T., Parker A., Perry J., Raine K.M., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P.J., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R.
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22068913; DOI=10.1073/pnas.1111840108
Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J., Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V., Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R., Ambudkar S.V., Gottesman M.M.
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=22347499; DOI=10.1371/journal.pone.0031628
Ruan X.-Y., Kocher J.-P.A., Pommier Y., Liu H.-F., Reinhold W.C.
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:E31628-E31628(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22944676; DOI=10.1515/hsz-2012-0195
Reinke S.O., Bayer M., Berger M., Hinderlich S., Blanchard V.
The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.
Biol. Chem. 393:731-747(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K.-I., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Sripayap P., Nagai T., Uesawa M., Kobayashi H., Tsukahara T., Ohmine K., Muroi K., Ozawa K.
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306(2014)

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Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:E92047-E92047(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28109323; DOI=10.1186/s13045-017-0396-0
Masetti R., Bertuccio S.N., Astolfi A., Chiarini F., Lonetti A., Indio V., De Luca M., Bandini J., Serravalle S., Franzoni M., Pigazzi M., Martelli A.M., Basso G., Locatelli F., Pession A.
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
J. Hematol. Oncol. 10:26.1-26.5(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29491412; DOI=10.1038/s41388-018-0150-2
Gerlach D., Tontsch-Grunt U., Baum A., Popow J., Scharn D., Hofmann M.H., Engelhardt H., Kaya O., Beck J., Schweifer N., Gerstberger T., Zuber J., Savarese F., Kraut N.
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Oncogene 37:2687-2701(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

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Establishment of a DeltaF508-CF promyelocytic cell line for cystic fibrosis research and drug screening.
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Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
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PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
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Cross-references
Cell line databases/resourcesCLO; CLO_0003775
CLO; CLO_0050972
MCCL; MCC:0000195
CLDB; cl1682
CLDB; cl1684
CLDB; cl1685
CLDB; cl1686
CLDB; cl1687
CLDB; cl1688
CLDB; cl1689
CLDB; cl1690
CLDB; cl1691
CLDB; cl1693
CCRID; 1101HUM-PUMC000037
CCRID; 1102HUM-NIFDC00098
CCRID; 3101HUMTCHu23
CCRID; 4201HUM-CCTCC00028
Cell_Model_Passport; SIDM00829
Cosmic-CLP; 905938
DepMap; ACH-000002
DSMZCellDive; ACC-3
IGRhCellID; HL60
LINCS_LDP; LCL-1054
Lonza; 64
SKY/M-FISH/CGH; 5609
TOKU-E; 1488
Anatomy/cell type resourcesBTO; BTO:0000738
Biological sample resourcesBioSample; SAMN01821559
BioSample; SAMN01821682
BioSample; SAMN03472768
BioSample; SAMN03473174
BioSample; SAMN10988245
ENCODE; ENCBS069ENC
ENCODE; ENCBS070ENC
ENCODE; ENCBS215JQI
ENCODE; ENCBS308XSW
ENCODE; ENCBS373UEY
ENCODE; ENCBS482VCU
ENCODE; ENCBS698WLF
ENCODE; ENCBS869DKF
ENCODE; ENCBS880XNW
Cell line collections (Providers)Abcam; ab282204 - Discontinued
AddexBio; C0003023/4977
ATCC; CCL-240
BCRC; 60027
BCRJ; 0104
CCTCC; GDC0027
CCTCC; GDC0028
CLS; 300209
DSMZ; ACC-3
ECACC; 98070106
ICLC; HTL95010
IZSLER; BS TCL 25
JCRB; IFO50022
JCRB; JCRB0085
JCRB; NIHS0086 - Discontinued
KCB; KCB 2014051YJ
KCLB; 10240
NCBI_Iran; C217
RCB; RCB0041
RCB; RCB3683
TKG; TKG 0345
Chemistry resourcesChEMBL-Cells; CHEMBL3307654
ChEMBL-Targets; CHEMBL383
GDSC; 905938
PharmacoDB; HL60_546_2019
PubChem_Cell_line; CVCL_0002
Encyclopedic resourcesWikidata; Q5630035
Experimental variables resourcesEFO; EFO_0002793

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