LNCap clone FGC人前列腺癌细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1095

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameLNCaP clone FGC
SynonymsLNCaP-Clone-FGC; LNCaP.FGC; LNCaP-FGC; LNCaP FGC; LNCAPCLONEFGC; LNCaP-ATCC
AccessionBTCC-1095
Resource Identification InitiativeTo cite this cell line use: LNCaP clone FGC (BTCC-1095)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Doubling time: 43 hours (PubMed=15389782); ~34 hours (ATCC=CRL-1740); ~36 hours (PBCF); 38.71 hours (GrayJW panel).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).
Misspelling: LNCaP.FCG; Note=Occasionally.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (DepMap).
Genome ancestrySource: PubMed=30894373

Origin% genome


African2.89
Native American0.31
East Asian, North0
East Asian, South2.4
South Asian8.61
European, North28.39
European, South57.41
DiseaseProstate carcinoma (NCIt: C4863)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0395 (LNCaP)
Children:



CVCL_C0BI (Abcam LNCaP clone FGC TMPRSS2 KO)CVCL_U984 (AILNCaP)CVCL_C0Z9 (JHU-LNCaP-SM)
CVCL_A1BN (LNCaP AR-NTD/pHage)CVCL_A1BM (LNCaP AR-V7/pHage)CVCL_A1BL (LNCaP AR-V7/pLenti)
CVCL_A4BQ (LNCaP clone FGC-Luc2)CVCL_W668 (LNCaP clone FGC.10)CVCL_B413 (LNCaP-17)
CVCL_WW88 (LNCaP-19)CVCL_B414 (LNCaP-34)CVCL_ZC87 (LNCaP-95)
CVCL_ZX07 (LNCAP-AAR)CVCL_4791 (LNCaP-AI)CVCL_C7XA (LNCaP-AR)
CVCL_5J30 (LNCaP-luc-M6)CVCL_WZ25 (LNCaP-SL)
Sex of cellMale
Age at sampling50Y
CategoryCancer cell line
STR profileSource(s): AddexBio; ATCC; CCRID; Cosmic-CLP; ECACC; KCLB; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133816
D3S135816
D5S81811,12
D7S8209.1,10.3 (AddexBio; ATCC; CCRID; TKG)
11 (Cosmic-CLP)
9 (RCB)
9,11 (ECACC; KCLB)
D8S117912,14
D13S31710,12
D16S53911
D18S5111,12
D19S43313.2,15
D21S1129,32.2
FGA19,20
TH019
TPOX8,9
vWA16,17,18 (RCB)
16,18 (AddexBio; ATCC; CCRID; Cosmic-CLP; ECACC; KCLB; TKG)

Run an STR similarity search on this cell line
Web pageshttps://www.atcc.org/en/support/technical-support/faqs/growth-rate-of-atcc-crl-1740
https://www.atcc.org/en/support/technical-support/faqs/crl-1740-growth-and-morphology
https://www.synapse.org/#!Synapse:syn31544554
Publications

PubMed=8104329; DOI=10.1002/pros.2990230206
Carroll A.G., Voeller H.J., Sugars L., Gelmann E.P.
p53 oncogene mutations in three human prostate cancer cell lines.
Prostate 23:123-134(1993)

PubMed=11172901; DOI=10.1016/S0165-4608(00)00339-3
Strefford J.C., Lillington D.M., Young B.D., Oliver R.T.D.
The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines: a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data.
Cancer Genet. Cytogenet. 124:112-121(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=15389782; DOI=10.1002/pros.20145
Gustavsson H., Welen K., Damber J.-E.
Transition of an androgen-dependent human prostate cancer cell line into an androgen-independent subline is associated with increased angiogenesis.
Prostate 62:364-373(2005)

PubMed=15833837; DOI=10.1158/0008-5472.CAN-04-3218
Lin B.-Y., White J.T., Lu W., Xie T., Utleg A.G., Yan X.-W., Yi E.C., Shannon P., Khrebtukova I., Lange P.H., Goodlett D.R., Zhou D.-X., Vasicek T.J., Hood L.E.
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease.
Cancer Res. 65:3081-3091(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630
Li Y., Chan S.-C., Brand L.J., Hwang T.H., Silverstein K.A.T., Dehm S.M.
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28145883; DOI=10.18632/oncotarget.14850
Nouri M., Caradec J., Lubik A.A., Li N., Hollier B.G., Takhar M., Altimirano-Dimas M., Chen M.-Q., Roshan-Moniri M., Butler M., Lehman M., Bishop J., Truong S., Huang S.-C., Cochrane D., Cox M., Collins C., Gleave M.E., Erho N., Alshalafa M., Davicioni E., Nelson C., Gregory-Evans S., Karnes R.J., Jenkins R.B., Klein E.A., Buttyan R.
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

PubMed=30305041; DOI=10.1186/s12885-018-4848-x
Jividen K., Kedzierska K.Z., Yang C.-S., Szlachta K., Ratan A., Paschal B.M.
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
BMC Cancer 18:960.1-960.20(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0007366
CLO; CLO_0007367
CLO; CLO_0051537
CLDB; cl3245
CLDB; cl4960
CLDB; cl5222
CCRID; 3101HUMSCSP5021
CCRID; 3101HUMTCHu173
Cell_Model_Passport; SIDM00683
Cosmic-CLP; 907788
DepMap; ACH-000977
Anatomy/cell type resourcesBTO; BTO:0006095
Biological sample resources4DN; 4DNSR4OQOB67
BioSample; SAMN03471417
BioSample; SAMN03472018
BioSample; SAMN05292444
BioSample; SAMN10988285
ENCODE; ENCBS089RMT
ENCODE; ENCBS184PDN
ENCODE; ENCBS235TSM
ENCODE; ENCBS260TRO
ENCODE; ENCBS386ENC
ENCODE; ENCBS387ENC
ENCODE; ENCBS418ENC
ENCODE; ENCBS421PUJ
ENCODE; ENCBS422ENC
ENCODE; ENCBS535BWO
ENCODE; ENCBS668DEO
ENCODE; ENCBS680JNS
ENCODE; ENCBS687TQL
ENCODE; ENCBS849SWQ
ENCODE; ENCBS851ZZS
ENCODE; ENCBS918PKZ
Cell line collections (Providers)Abcam; ab275470
AddexBio; C0019003/4953
ATCC; CRL-1740
BCRC; 60088
BCRJ; 0149
ECACC; 89110211
ICLC; HTL99011
IZSLER; BS TCL 148
KCB; KCB 200732YJ
KCLB; 21740
RCB; RCB2144
TKG; TKG 0603
Chemistry resourcesChEMBL-Cells; CHEMBL3308342
ChEMBL-Targets; CHEMBL2366172
GDSC; 907788
PharmacoDB; LNCaPCloneFGC_851_2019
PubChem_Cell_line; CVCL_1379
Encyclopedic resourcesWikidata; Q54902825
Experimental variables resourcesEFO; EFO_0005726

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