LX-2人肝星状细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1097

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameLX-2
SynonymsLieming Xu-2
AccessionBTCC-1097
Resource Identification InitiativeTo cite this cell line use: LX-2 (BTCC-1097)
CommentsCharacteristics: Able to grow under reduced serum conditions (1% FBS) (PubMed=15591520).
Doubling time: ~3-4 days (PubMed=15591520); 53.3 +- 2.3 hours (PubMed=21930125).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Extracellular matrix proteome analysis.
Omics: Deep quantitative proteome analysis.
Anecdotal: Cell line name is derived from the name of the first author of the original paper.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatic stellate cell; CL=CL_0000632.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_5790 (LX-1 [Human HSC])
Sex of cellMale
Age at samplingAge unspecified
CategoryTransformed cell line
STR profileSource(s): Genomics_Center_BCF_Technion; Millipore; PubMed=24116068

Markers:
AmelogeninX,Y
CSF1PO10,12
D1S165612
D2S44111,14
D2S133817
D3S135813,15
D5S81811,12
D7S82011
D8S117913
D10S124813
D12S39115,17
D13S31711,13
D16S53913
D18S5112
D19S43313,15.2
D21S1128,31
D22S104516
DYS39110
FGA21,26
Penta D12,13,15
Penta E5,21
TH019.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=15591520; DOI=10.1136/gut.2004.042127
Xu L.-M., Hui A.Y., Albanis E., Arthur M.J., O'Byrne S.M., Blaner W.S., Mukherjee P., Friedman S.L., Eng F.J.
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
Gut 54:142-151(2005)

PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x
Herrmann J., Gressner A.M., Weiskirchen R.
Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
J. Cell. Mol. Med. 11:704-722(2007)

PubMed=19085953; DOI=10.1002/hep.22697
Guo J.-S., Loke J., Zheng F., Hong F., Yea S., Fukata M., Tarocchi M., Abar O.T., Huang H.-J., Sninsky J.J., Friedman S.L.
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
Hepatology 49:960-968(2009)

PubMed=21930125; DOI=10.1016/j.yexmp.2011.09.002
Castilho-Fernandes A., de Almeida D.C., Fontes A.M., Melo F.U.F., Picanco-Castro V., Cristina Correa de Freitas M., Orellana M.D., Palma P.V.B., Hackett P.B., Friedman S.L., Covas D.T.
Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells.
Exp. Mol. Pathol. 91:664-672(2011)

PubMed=22694338; DOI=10.1021/pr3000927
Rashid S.T., Humphries J.D., Byron A., Dhar A., Askari J.A., Selley J.N., Knight D., Goldin R.D., Thursz M., Humphries M.J.
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.
J. Proteome Res. 11:4052-4064(2012)

PubMed=24116068; DOI=10.1371/journal.pone.0075692
Weiskirchen R., Weimer J., Meurer S.K., Kron A., Seipel B., Vater I., Arnold N., Siebert R., Xu L.-M., Friedman S.L., Bergmann C.
Genetic characteristics of the human hepatic stellate cell line LX-2.
PLoS ONE 8:E75692-E75692(2013)

PubMed=34884585; DOI=10.3390/ijms222312782
Schinagl M., Tomin T., Gindlhuber J., Honeder S., Pfleger R., Schittmayer M., Trauner M., Birner-Gruenberger R.
Proteomic changes of activated hepatic stellate cells.
Int. J. Mol. Sci. 22:12782.1-12782.17(2021)

Cross-references
Cell line databases/resourcesLonza; 616
SKY/M-FISH/CGH; 5853
Anatomy/cell type resourcesBTO; BTO:0003516
Cell line collections (Providers)CLS; 305039
Millipore; SCC064
Chemistry resourcesChEMBL-Cells; CHEMBL4879539
Encyclopedic resourcesWikidata; Q54903298
Proteomic databasesPRIDE; PRD000680
PRIDE; PXD029121

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