| Cell line name | MCF-7 | ||||||||||||||||||||||||||||||||||||||||
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| Synonyms | MCF 7; MCF.7; MCF7; Michigan Cancer Foundation-7; ssMCF-7; ssMCF7; MCF7/WT; MCF7-CTRL; IBMF-7 | ||||||||||||||||||||||||||||||||||||||||
| Accession | BTCC-1099 | ||||||||||||||||||||||||||||||||||||||||
| Resource Identification Initiative | To cite this cell line use: MCF-7 (BTCC-1099) | ||||||||||||||||||||||||||||||||||||||||
| Comments | Group: Space-flown cell line (cellonaut). Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: ENCODE project common cell types; tier 2. Part of: JFCR39 cancer cell line panel. Part of: JFCR45 cancer cell line panel. Part of: GrayJW breast cancer cell line panel. Part of: ICBP43 breast cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. Part of: NCI-60 cancer cell line panel. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12584. Registration: Chiron Master Culture Collection; CMCC 10377 (CMCC #10377). Population: Caucasian. Doubling time: 1.8 days (PubMed=9671407); 80 hours (PubMed=25984343); 24 hours (PubMed=9488600); 31.2 hours (PubMed=22628656); 25.3 hours (PubMed=24389870); 24.4 hours (PubMed=34238275); ~50 hours (Note=With a range of 30-72 hours) (DSMZ=ACC-115); 25.4 hours (NCI-DTP=MCF7); ~38 hours (PBCF); 56.47 hours (GrayJW panel). Microsatellite instability: Stable (MSS) (PubMed=12661003; PubMed=23671654; Sanger). Omics: Array-based CGH. Omics: CTCF ChIP-seq epigenome analysis. Omics: H2BK120ub ChIP-seq epigenome analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K23ac ChIP-seq epigenome analysis. Omics: H3K27ac ChIP-seq epigenome analysis. Omics: H3K27me3 ChIP-seq epigenome analysis. Omics: H3K36me3 ChIP-seq epigenome analysis. Omics: H3K4me1 ChIP-seq epigenome analysis. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: H3K79me2 ChIP-seq epigenome analysis. Omics: H3K9ac ChIP-seq epigenome analysis. Omics: H3K9me3 ChIP-seq epigenome analysis. Omics: H4K8ac ChIP-seq epigenome analysis. Omics: CNV analysis. Omics: Deep antibody staining analysis. Omics: Deep exome analysis. Omics: Deep phosphoproteome analysis. Omics: Deep proteome analysis. Omics: Deep quantitative proteome analysis. Omics: DNA methylation analysis. Omics: Fluorescence phenotype profiling. Omics: Glycoproteome analysis by proteomics. Omics: lncRNA expression profiling. Omics: Metabolome analysis. Omics: miRNA expression profiling. Omics: Myristoylated proteins analysis by proteomics. Omics: N-glycan profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: shRNA library screening. Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Omics: Transcriptome analysis by serial analysis of gene expression (SAGE). Omics: Transcriptome analysis by single cell RNAseq. Omics: Virome analysis using proteomics. Anecdotal: This is the first hormone-responsive breast cancer cell line to have been established. Anecdotal: Have been flown in space on Foton-12 to study cytoskeleton architecture in microgravity (PubMed=11292682; PubMed=15002416). Anecdotal: Used in a study utilising the fruit fly's olfactory system to detect cancer cells (PubMed=24389870). Donor information: Helen Marion Mallon (sister Catherine Frances), the patient from which this cell line is derived was a nun at the Immaculate Heart of Mary convent in Monroe, Michigan (CelloPub=CLPUB00336). Misspelling: MFC-7; Note=Occasionally. Misspelling: MFC7; Note=Occasionally. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. | ||||||||||||||||||||||||||||||||||||||||
| Sequence variations |
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| HLA typing | Source: PubMed=15748285
Source: PubMed=25960936
Source: PubMed=26589293
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| Genome ancestry | Source: PubMed=30894373
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| Disease | Invasive breast carcinoma of no special type (NCIt: C4194) | ||||||||||||||||||||||||||||||||||||||||
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||||||
| Cell line collections (Providers) | Abcam; ab257303 Abcam; ab271144 Abcam; ab277916 Abcam; ab288560 AddexBio; C0006008/402 ATCC; HTB-22 BCRC; 60436 BCRJ; 0162 CCTCC; GDC0055 CLS; 300273 DSMZ; ACC-115 ECACC; 86012803 IBRC; C10082 IBRC; C10682 ICLC; HTL95021 IZSLER; BS TCL 38 JCRB; JCRB0134 JCRB; NIHS0200 - Discontinued KCB; KCB 200529YJ KCB; KCB 200831YJ KCLB; 30022 NCBI_Iran; C135 NCI-DTP; MCF7 RCB; RCB1904 TKG; TKG 0479 |
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| Chemistry resources | ChEMBL-Cells; CHEMBL3308403 ChEMBL-Targets; CHEMBL387 GDSC; 905946 PharmacoDB; MCF7_895_2019 PubChem_Cell_line; CVCL_0031 |
| Encyclopedic resources | Wikidata; Q1881253 |
| Experimental variables resources | EFO; EFO_0001203 |
