MT-4人急性淋巴母细胞白血病细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1116

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameMT-4
SynonymsMT4
AccessionBTCC-1116
Resource Identification InitiativeTo cite this cell line use: MT-4 (BTCC-1116)
CommentsProblematic cell line: Partially contaminated. Two different lots formerly distributed by NIH-ARP; 13 P7 3/9/92 and 150048; were shown not to be authentic MT-4 (PubMed=9261343; PubMed=31554688).
Population: Japanese.
Characteristics: Was established by co-cultivation of cells from a 50 year old male T-cell leukemia patient with cord leukocytes from a male infant (CelloPub=CLPUB00542).
Virology: HTLV-1 producing cell line. Expresses Tax. Is permissive for replication of an HIV-1 gp41 mutant lacking the cytoplasmic tail.
Doubling time: ~30 hours (Note=Lot 102799) (JCRB=JCRB1216).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
Cell type: T-cell; CL=CL_0000084.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:


CVCL_RW54 (MT4/HIV-1)CVCL_RW55 (MT4C5)
Sex of cellMale
Age at sampling<1D
CategoryTransformed cell line
STR profileSource(s): JCRB; PubMed=31554688; PubMed=32938764

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135817
D5S81810,11
D7S8208,9.3,10 (JCRB_JCRB1216)
8,10 (JCRB_JCRB0135; PubMed=31554688; PubMed=32938764)
D8S117910,15
D13S31712
D16S5399,12
D18S5113
D21S1128,30.3
FGA23
Penta D10,13
Penta E5,15
TH017
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-117.html
Publications

CLPUB00542
Miyoshi I., Taguchi H., Kubonishi I., Yoshimoto S., Ohtsuki Y., Shiraishi Y., Akagi T.
Type C virus-producing cell lines derived from adult T cell leukemia.
Gann Monogr. Cancer Res. 28:219-228(1982)

PubMed=2413616; DOI=10.1016/0042-6822(85)90010-8
Harada S., Koyanagi Y., Yamamoto N.
Infection of human T-lymphotropic virus type-I (HTLV-I)-bearing MT-4 cells with HTLV-III (AIDS virus): chronological studies of early events.
Virology 146:272-281(1985)

PubMed=1765142; DOI=10.1016/0014-5793(91)81402-t
Orita S., Saiga A., Takagi S., Tanaka T., Okumura K., Aono Y., Hinuma Y., Igarashi H.
A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein.
FEBS Lett. 295:127-134(1991)

PubMed=1364232
Gyuris A., Vajda G., Foldes I.
Establishment of an MT4 cell line persistently producing infective HIV-1 particles.
Acta Microbiol. Hung. 39:271-279(1992)

PubMed=8927062
Susloparov M.A., Krendel'shchikov A.V., Bakhtina M.M., Bedristov A.I., Babkin I.V., Gutorov V.V., Eroshkin A.M., Mamaeva O.A.
Cloning of proviral DNA sequences of the human T-cell leukemia virus type 1 (HTLV-1) from the genome of cultured MT-4 cells.
Mol. Genet. Mikrobiol. Virusol. 1996:32-39(1996)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x
Kawasaki N., Matsuo Y., Yoshino T., Yanai H., Oka T., Teramoto N., Liu C., Kondo E., Minowada J., Akagi T.
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=9261343; DOI=10.1128/JVI.71.9.6277-6278.1997
Jeang K.-T., Derse D.D., Matocha M., Sharma O.
Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT4 cells: recall of MT4 cells distributed by the NIH AIDS Research and Reference Reagent Program.
J. Virol. 71:6277-6278(1997)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=31554688; DOI=10.1128/JVI.01390-19
Fernandez M.V., Delviks-Frankenberry K.A., Scheiblin D.A., Happel C., Pathak V.K., Freed E.O.
Authentication analysis of MT-4 cells distributed by the NIH AIDS Reagent Program.
J. Virol. 93:e01390.19.1-e01390.19.8(2019)

PubMed=32938764; DOI=10.1128/JVI.01334-20
Fernandez M.V., Hoffman H.K., Pezeshkian N., Tedbury P.R., van Engelenburg S.B., Freed E.O.
Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail.
J. Virol. 94:e01334.20.1-e01334.20.27(2020)

Cross-references
Cell line databases/resourcesCLO; CLO_0007891
CLDB; cl3594
CLDB; cl3599
Anatomy/cell type resourcesBTO; BTO:0003030
Biological sample resourcesBioSample; SAMN03470803
BioSample; SAMN03472442
Cell line collections (Providers)ECACC; 08081402
HIVReagentProgram; ARP-120
JCRB; JCRB0135 - Discontinued
JCRB; JCRB1216 - Discontinued
JCRB; NIHS0145 - Discontinued
JCRB; NIHS0529 - Discontinued
KCB; KCB 200308YJ
Chemistry resourcesChEMBL-Cells; CHEMBL3308375
ChEMBL-Targets; CHEMBL388
PubChem_Cell_line; CVCL_2632
Encyclopedic resourcesWikidata; Q54906940
Polymorphism and mutation databasesCosmic; 1191697

更多>>相关产品

总部地址:北京市怀柔区渤海镇怀沙路536号

关注我们
在线咨询
在线客服
电话咨询
微信客服
返回顶部