THLE-2人肝永生化细胞(STR鉴定正确)

价 格:¥3600

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1420

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameTHLE-2
SynonymsTHLE2; Transformed Human Liver Epithelial-2
AccessionBTCC-1420
Resource Identification InitiativeTo cite this cell line use: THLE-2 (BTCC-1420)
CommentsGroup: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10149.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellMale
Age at samplingAdult
CategoryTransformed cell line
STR profileSource(s): AddexBio=T0015001/4912; ATCC=CRL-2706; IZSLER=BS CL 194

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133817,23
D3S135814,15
D5S81811,13
D7S82010,12
D8S117913
D13S3178,12
D16S53911,13
D18S5113,16
D19S43314
D21S1130,32.2
FGA22,24
Penta D10,13
Penta E12,13
TH017,9.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

DOI=10.1007/978-1-4612-0411-4_31
Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A., Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.
A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York; USA (1990)

PubMed=7685115; DOI=10.1073/pnas.90.11.5123; PMCID=PMC46667
Pfeifer A.M.A., Cole K.E., Smoot D.T., Weston A., Groopman J.D., Shields P.G., Vignaud J.-M., Juillerat M., Lipsky M.M., Trump B.F., Lechner J.F., Harris C.C.
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.
Proc. Natl. Acad. Sci. U.S.A. 90:5123-5127(1993)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R.V., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

Patent=US5529920
Cole K.H., Lechner J.F., Reddel R.R., Harris C.C., Pfeifer A.M.A.
Human liver epithelial cell line and culture media therefor.
Patent number US5529920, 25-Jun-1996

Patent=US5759765
Harris C.C., Cole K.H., Lechner J.F., Reddel R.R.
Human liver epithelial cell lines.
Patent number US5759765, 02-Jun-1998

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

Cross-references
Cell line collections (Providers)AddexBio; T0015001/4912
ATCC; CRL-2706
IZSLER; BS CL 194
Cell line databases/resourcesCLO; CLO_0009346
Biological sample resourcesBioSample; SAMN03471297
Chemistry resourcesChEMBL-Cells; CHEMBL4295456
ChEMBL-Targets; CHEMBL4296500
PubChem_Cell_line; CVCL_3803
Encyclopedic resourcesWikidata; Q54972310
Polymorphism and mutation databasesCosmic; 2162542
IARC_TP53; 23553

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