UM-SCC-1人口底鳞癌细胞(STR鉴定正确)

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1448

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameUM-SCC-1
SynonymsUMSCC-1; UM-SCC1; UMSCC1; UM-SCC-01; SCC-1; SCC1; University of Michigan-Squamous Cell Carcinoma-1
AccessionBTCC-1448
Resource Identification InitiativeTo cite this cell line use: UM-SCC-1 (RRID:BTCC-1448)
CommentsPart of: MD Anderson Cell Lines Project.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Miscellaneous: The STR profile undergoes a loss of the Amelogenin Y, D8S1179 13 and FGA 22 alleles at passages >=150 (PubMed=19760794).
Caution: Indicated as originating from a 60 year old patient in PubMed=3855324 and from a 72 year old in PubMed=1851275 and PubMed=18006756.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
DiseaseFloor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_L893 (1Cc8)CVCL_4V02 (SCC-1-Cet-R)CVCL_4V03 (SCC-1-Erl-R)
CVCL_4V04 (SCC-1-Gef-R)CVCL_1Q88 (T409)CVCL_4912 (Tu 167)
Sex of cellMale
Age at sampling72Y
CategoryCancer cell line
STR profileSource(s): Millipore=SCC070; PubMed=19760794; PubMed=21868764; PubMed=36912284

Markers:
AmelogeninX (PubMed=21868764; PubMed=36912284)
X,Y (Millipore=SCC070; PubMed=19760794)
CSF1PO10,12
D2S133820,22
D3S135818
D5S81810,13
D7S8209,12
D8S117913,16
D13S3178,11
D16S53912,13
D18S5118
D19S43312
D21S1127
FGA18,22 (PubMed=19760794)
22 (Millipore=SCC070)
Penta D9
Penta E13
TH016
TPOX8,11
vWA15,18

Run an STR similarity search on this cell line
Web pagesInfo; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Baker S.R.
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D., Carey T.E.
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8725545; DOI=10.3109/00016489609137854
Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.
Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma.
Acta Oto-Laryngol. 116:341-344(1996)

PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x
Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O., Rytomaa T.
p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.
Cell Prolif. 29:219-230(1996)

PubMed=12884349; DOI=10.1002/hed.10274
Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A., Johnson G., Wolf G.T., Fisher S.G., Carey T.E.
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591
Friedman J., Nottingham L.K., Duggal P., Pernas F.G., Yan B., Yang X.-P., Chen Z., Van Waes C.
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clin. Cancer Res. 13:6568-6578(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30527230; DOI=10.1016/j.oraloncology.2018.10.031; PMCID=PMC6349383
Ludwig M.L., Kulkarni A., Birkeland A.C., Michmerhuizen N.L., Foltin S.K., Mann J.E., Hoesli R.C., Devenport S.N., Jewell B.M., Shuman A.G., Spector M.E., Carey T.E., Jiang H., Brenner J.C.
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.
Oral Oncol. 87:144-151(2018)

PubMed=36912284; DOI=10.1002/ijc.34506
Nguyen H.T., Tang W.-L., Webster A.L.H., Whiteaker J.R., Chandler C.M., Errazquin Ciudad R., Roohollahi K., Fritzke M., Hoskins E.E., Jonlin E.C., Wakefield L., Sullivan L.B., Chen E.Y., Dorsman J.C., Brakenhoff R.H., Paulovich A.G., Grompe M., Garcia-Escudero R., Wells S.I., Smogorzewska A., Monnat R.J. Jr.
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Int. J. Cancer 153:183-196(2023)

Cross-references
Cell line collections (Providers)Millipore; SCC070
Cell line databases/resourcescancercelllines; CVCL_7707
Anatomy/cell type resourcesBTO; BTO_0003138
Chemistry resourcesChEMBL-Cells; CHEMBL3707167
ChEMBL-Targets; CHEMBL3707168
PubChem_Cell_line; CVCL_7707
Encyclopedic resourcesWikidata; Q54990789
Gene expression databasesGEO; GSM3631262
Polymorphism and mutation databasesCosmic; 1483455
Cosmic; 1530751
Cosmic; 2131858
IARC_TP53; 21100
Progenetix; CVCL_7707

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