RPMI 2650人鼻中隔鳞状癌细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1152

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameRPMI-2650
SynonymsRPMI 2650; RPMI2650; R.P.M.I. #2650; Roswell Park Memorial Institute 2650
AccessionBTCC-1152
Resource Identification InitiativeTo cite this cell line use: RPMI-2650 (BTCC-1152)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Population: Caucasian.
Doubling time: ~40-50 hours (DSMZ=ACC-287).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: CCL30; Note=Based on the ATCC catalog number.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 13575; BRD4 + HGNC; 29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=25485619).
HLA typingSource: PubMed=77569
Class I
HLA-AA*02,03
HLA-BB*07,w22
HLA-CC*w03,w06

Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*07:02,35:08
HLA-CC*03:03,07:02
Genome ancestrySource: PubMed=30894373

Origin% genome


African0.38
Native American0.9
East Asian, North1.71
East Asian, South0
South Asian0
European, North68.78
European, South28.23
DiseaseHead and neck squamous cell carcinoma (NCIt: C34447)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellMale
Age at sampling52Y
CategoryCancer cell line
STR profileSource(s): ATCC; CLS; Cosmic-CLP; DepMap; DSMZ; ECACC; JCRB; KCLB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO9,11
D2S133820,25
D3S135817
D5S81812,13
D7S8208,11
D8S11799,13
D13S31711,12
D16S53911,12
D18S5116
D19S43314,16
D21S1128,33.2
FGA23,25
Penta D9,10
Penta E11,19
TH016,8
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=14082866
Moore G.E., Mount D., Tara G., Schwartz N.
Growth of human tumor cells in suspension cultures.
Cancer Res. 23:1735-1741(1963)

PubMed=5831238; DOI=10.1016/0014-4827(65)90022-4
Moorhead P.S.
Human tumor cell line with a quasi-diploid karyotype (RPMI 2650).
Exp. Cell Res. 39:190-196(1965)

DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=174085; DOI=10.1073/pnas.72.12.4971
Stiles C.D., Desmond W. Jr., Sato G.H., Saier M.H. Jr.
Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice.
Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975)

PubMed=1260760
Stiles C.D., Desmond W. Jr., Chuman L.M., Sato G.H., Saier M.H. Jr.
Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse.
Cancer Res. 36:1353-1360(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=6277475
Frampton R.J., Suva L.J., Eisman J.A., Findlay D.M., Moore G.E., Moseley J.M., Martin T.J.
Presence of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture.
Cancer Res. 42:1116-1119(1982)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0008869
CLO; CLO_0008876
CLDB; cl4174
CLDB; cl4175
CLDB; cl4176
Cell_Model_Passport; SIDM00809
Cosmic-CLP; 909700
DepMap; ACH-001385
DSMZCellDive; ACC-287
IGRhCellID; RPMI2650%20GSE9585
LINCS_LDP; LCL-1881
Anatomy/cell type resourcesBTO; BTO:0004205
Biological sample resourcesBioSample; SAMN01821660
BioSample; SAMN01821717
BioSample; SAMN03473151
Cell line collections (Providers)ATCC; CCL-30
BCRC; 60296
CLS; 300323
DSMZ; ACC-287
ECACC; 88031602
IZSLER; BS TCL 59
JCRB; JCRB9058
KCLB; 10030
Chemistry resourcesChEMBL-Cells; CHEMBL3308780
ChEMBL-Targets; CHEMBL1075566
GDSC; 909700
PharmacoDB; RPMI2650_1324_2019
PubChem_Cell_line; CVCL_1664
Encyclopedic resourcesWikidata; Q54951175
Experimental variables resourcesEFO; EFO_0006478
Gene expression databasesArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM1374853
GEO; GSM1374854
GEO; GSM1670386
Polymorphism and mutation databasesCosmic; 686978
Cosmic; 909700
Cosmic; 1006465
Cosmic; 1017789
Cosmic; 1041670
Cosmic; 1339925
Cosmic; 2043886
IARC_TP53; 21290
Sequence databasesEGA; EGAS00001000610

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