VCaP人前列腺癌细胞

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1201

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameVCaP
SynonymsVCAP; Vcap; Vertebral Cancer of the Prostate
AccessionBTCC-1201
Resource Identification InitiativeTo cite this cell line use: VCaP (BTCC-1201)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Characteristics: Established from a xenograft produced by implantation of tumor cells in a SCID mouse.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=21698104).
Doubling time: 220 hours (PubMed=25984343); ~53 hours (ATCC=CRL-2876); ~51 hours (PBCF); 126.45 hours (GrayJW panel).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
Genome ancestrySource: PubMed=30894373

Origin% genome


African0
Native American0.05
East Asian, North1.4
East Asian, South0
South Asian0.98
European, North69.8
European, South27.77
DiseaseProstate carcinoma (NCIt: C4863)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_A1BP (VCaP AR-V7/pHag)CVCL_A0BX (VCaP-CR)CVCL_RA58 (VCaP-EnzR)
CVCL_C0QQ (VCaP-R)CVCL_WZ27 (VCaP-SL)
Originate from same individualCVCL_2025 ! DuCaP
Sex of cellMale
Age at sampling59Y
CategoryCancer cell line
STR profileSource(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; PubMed=14518029; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817,25
D3S135814,15
D5S81812
D6S104311
D7S8209,12
D8S117912,13
D12S39121,23
D13S31711,12
D16S5399
D18S5113
D19S43313
D21S1131
FGA21,26 (PubMed=25877200)
26 (CLS)
Penta D9
Penta E10,12
TH019.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Web pageshttps://en.wikipedia.org/wiki/VCaP
https://www.phe-culturecollections.org.uk/media/161930/vcap-cell-line-profile-v2.pdf
https://www.atcc.org/en/support/technical-support/faqs/atcc-crl-2876-growth-and-morphology
https://www.synapse.org/#!Synapse:syn31544522
Publications

PubMed=11317522
Korenchuk S., Lehr J.E., McLean L., Lee Y.-G., Whitney S., Vessella R.L., Lin D.L., Pienta K.J.
VCaP, a cell-based model system of human prostate cancer.
In Vivo 15:163-168(2001)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
van Bokhoven A., Caires A., Maria M.D., Schulte A.P., Lucia M.S., Nordeen S.K., Miller G.J., Varella-Garcia M.
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=21698104; DOI=10.1371/journal.pone.0020874
Sfanos K.S., Aloia A.L., Hicks J.L., Esopi D.M., Steranka J.P., Shao W., Sanchez-Martinez S., Yegnasubramanian S., Burns K.H., Rein A., De Marzo A.M.
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.
PLoS ONE 6:E20874-E20874(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23447416; DOI=10.1002/path.4186
Weier C., Haffner M.C., Mosbruger T., Esopi D.M., Hicks J.L., Zheng Q., Fedor H., Isaacs W.B., De Marzo A.M., Nelson W.G., Yegnasubramanian S.
Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer.
J. Pathol. 230:174-183(2013)

PubMed=23615946; DOI=10.1007/s00439-013-1308-1
Teles Alves I., Hiltemann S., Hartjes T., van der Spek P.J., Stubbs A., Trapman J., Jenster G.
Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line.
Hum. Genet. 132:709-713(2013)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y.-H., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28145883; DOI=10.18632/oncotarget.14850
Nouri M., Caradec J., Lubik A.A., Li N., Hollier B.G., Takhar M., Altimirano-Dimas M., Chen M.-Q., Roshan-Moniri M., Butler M., Lehman M., Bishop J., Truong S., Huang S.-C., Cochrane D., Cox M., Collins C., Gleave M.E., Erho N., Alshalafa M., Davicioni E., Nelson C., Gregory-Evans S., Karnes R.J., Jenkins R.B., Klein E.A., Buttyan R.
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

PubMed=30305041; DOI=10.1186/s12885-018-4848-x
Jividen K., Kedzierska K.Z., Yang C.-S., Szlachta K., Ratan A., Paschal B.M.
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
BMC Cancer 18:960.1-960.20(2018)

PubMed=30244336; DOI=10.1007/s00345-018-2501-6
Samli H., Samli M., Vatansever B., Ardicli S., Aztopal N., Dincel D., Sahin A., Balci F.
Paclitaxel resistance and the role of miRNAs in prostate cancer cell lines.
World J. Urol. 37:1117-1126(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=34402095; DOI=10.1002/pros.24210
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J.L., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCCRID; 3101HUMSCSP5034
CCRID; 3101HUMTCHu220
Cell_Model_Passport; SIDM01077
Cosmic-CLP; 1299075
DepMap; ACH-000115
LINCS_LDP; LCL-1147
Anatomy/cell type resourcesBTO; BTO:0003215
Biological sample resourcesBioSample; SAMN03473238
BioSample; SAMN05292448
BioSample; SAMN10988209
ENCODE; ENCBS316RCQ
ENCODE; ENCBS626UQL
Cell line collections (Providers)AddexBio; C0019001/73
ATCC; CRL-2876
CLS; 300631
ECACC; 06020201
IZSLER; BS TCL 234
Chemistry resourcesChEMBL-Cells; CHEMBL4295435
ChEMBL-Targets; CHEMBL4296508
GDSC; 1299075
PharmacoDB; VCaP_1653_2019
PubChem_Cell_line; CVCL_2235
Encyclopedic resourcesWikidata; Q29511246
Experimental variables resourcesEFO; EFO_0007752

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