NK-92MI人恶性非霍奇金淋巴瘤患者的自然杀伤细胞

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1217

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameNK-92MI
SynonymsNK-92 MI; NK-92 mi; NK92-MI; NK92MI; NK-92 transfected with MFG-hIL2
AccessionBTCC-1217
Resource Identification InitiativeTo cite this cell line use: NK-92MI (BTCC-1217)
CommentsGroup: Patented cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-6671.
Characteristics: No longer dependent on IL2.
Microsatellite instability: Stable (MSS) (Sanger).
Transfected with: HGNC; 6001; IL2.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Caution: This cell line is exclusively owned and controlled by NantKwest, Inc. NantKwest and its affiliate, Brink Biologics, Inc. are the sole authorized distributors for both commercial and non-commercial research requestors. There are no other authorized commercial and non-commercial suppliers of NK-92MI. Contact NantKwest and Brink Biologics for information concerning current inventory and cell line use and support.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Natural killer cell; CL=CL_0000623.
Genome ancestrySource: PubMed=30894373

Origin% genome


African1.91
Native American0.5
East Asian, North2.04
East Asian, South0
South Asian0
European, North62.71
European, South32.85
DiseaseNatural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_2142 (NK-92)
Children:



CVCL_XZ60 (NK-92MI human CD16a-V158)CVCL_JX95 (NK-92MIhCD16)CVCL_JX96 (NK-92MIhCD64)
Sex of cellMale
Age at sampling50Y
CategoryCancer cell line
STR profileSource(s): ATCC; CCRID; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815
D5S81812,13
D7S82010,11
D8S117912,15
D13S3179,12
D16S53911,12
D18S5112,17
D21S1131.2,32
FGA20,22
Penta D10,12
Penta E12
TH016,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=10365666; DOI=10.1089/10430349950018030
Tam Y.K., Maki G., Miyagawa B., Hennemann B., Tonn T., Klingemann H.-G.
Characterization of genetically altered, interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy.
Hum. Gene Ther. 10:1359-1373(1999)

Patent=US8034332
Klingemann H.-G.
Interleukin-secreting natural killer cell lines and methods of use.
Patent number US8034332, 11-Oct-2011

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0008178
CCRID; 1102HUM-NIFDC00065
Cell_Model_Passport; SIDM01201
Cosmic-CLP; 1330981
DepMap; ACH-002289
LINCS_LDP; LCL-1127
Cell line collections (Providers)ATCC; CRL-2408
BCRC; 60438 - Discontinued
KCB; KCB 200677YJ
Chemistry resourcesGDSC; 1330981
PharmacoDB; NK92MI_1160_2019
Encyclopedic resourcesWikidata; Q54930658
Gene expression databasesGEO; GSM1670278
Proteomic databasesPRIDE; PXD030304

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