HUT-78人T淋巴细胞白血病细胞

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1241

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameHuT 78
SynonymsHut 78; HUT 78; HuT-78; HUT-78; HuT78; Hut78; HUT78; NCI-H78
AccessionBTCC-1241
Resource Identification InitiativeTo cite this cell line use: HuT 78 (BTCC-1241)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Population: Caucasian.
Doubling time: 26 hours (PubMed=6244013); ~65 hours (ATCC=TIB-161); 26 hours (HIVReagentProgram=ARP-89).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Virome analysis using RNAseq.
Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (PubMed=20215515).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=12068308; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (PubMed=2144611; DepMap).
Genome ancestrySource: PubMed=30894373

Origin% genome


African0.32
Native American0.76
East Asian, North2.56
East Asian, South0
South Asian0.32
European, North68.01
European, South28.04
DiseaseSezary syndrome (NCIt: C3366)
Sezary syndrome (ORDO: Orphanet_3162)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_1240 (H9)CVCL_X617 (HUT 78/HIV-1SF2)CVCL_X682 (HUT 78/HIV-2D194)
CVCL_X683 (HUT 78/HIV-2D205)CVCL_X611 (HUT 78/SIV-BK28)CVCL_X616 (HUT 78/SIV-BK44)
CVCL_X609 (HUT 78/SIVmac251)CVCL_0325 (HuT78B1)CVCL_9472 (PM1)
Sex of cellMale
Age at sampling53Y
CategoryCancer cell line
STR profileSource(s): ATCC; CCRID; CLS; PubMed=11416159; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,25
D3S135815,16
D5S81811,12
D7S8208 (PubMed=25877200)
8,11 (ATCC; CCRID; CLS; RCB; TKG)
D8S117912,14
D13S3178,12
D16S53911,12
D18S5118
D19S43314
D21S1130
FGA21,25
Penta D9
Penta E13,15
TH018,9
TPOX8,9
vWA14,15

Run an STR similarity search on this cell line
Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-70.html
http://www.nibsc.org/Default.aspx?pageid=597&id=0002&theme=default
Publications

PubMed=6244013; DOI=10.1182/blood.V55.3.409.409
Gazdar A.F., Carney D.N., Bunn P.A. Jr., Russell E.K., Jaffe E.S., Schechter G.P., Guccion J.G.
Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.
Blood 55:409-417(1980)

PubMed=6975346; DOI=10.1084/jem.154.5.1403
Gootenberg J.E., Ruscetti F.W., Mier J.W., Gazdar A.F., Gallo R.C.
Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor.
J. Exp. Med. 154:1403-1418(1981)

PubMed=6954533; DOI=10.1073/pnas.79.7.2194
Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A., Aaronson S.A., Wong-Staal F.
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6151082; DOI=10.1016/s0140-6736(84)91666-0
Popovic M., Read-Connole E., Gallo R.C.
T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III.
Lancet 324:1472-1473(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3495441; DOI=10.1002/eji.1830170503
Kanowith-Klein S., Saxon A., Uittenbogaart C.H.
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990
Cheng J., Haas M.
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=2193399; DOI=10.1126/science.2193399
Rubinstein E.
The untold story of HUT78.
Science 248:1499-1507(1990)

PubMed=8127147
Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8806089; DOI=10.1002/jcb.240630502
Gazdar A.F., Minna J.D.
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806090; DOI=10.1002/jcb.240630503
Bunn P.A. Jr., Foss F.M.
T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomas (ATLL).
J. Cell. Biochem. 63 Suppl. 24:12-23(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10570904; DOI=10.1007/s100380050178
Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A., Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
J. Hum. Genet. 44:357-363(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0004304
CLO; CLO_0051010
MCCL; MCC:0000233
CLDB; cl1778
CLDB; cl1779
CCRID; 1101HUM-PUMC000190
CCRID; 3101HUMTCHu206
Cell_Model_Passport; SIDM00851
CGH-DB; 9026-4
DepMap; ACH-000509
IGRhCellID; HuT78
LINCS_LDP; LCL-2005
Lonza; 813
TOKU-E; 1977
Anatomy/cell type resourcesBTO; BTO:0001945
Biological sample resourcesBioSample; SAMN01821566
BioSample; SAMN03471940
BioSample; SAMN03473203
BioSample; SAMN10987600
Cell line collections (Providers)ATCC; TIB-161
ATCC; CRM-TIB-161
BCRC; 60522
BCRJ; 0370
CCTCC; GDC0307
CLS; 300338
ECACC; 88041901
HIVReagentProgram; ARP-89
KCLB; 90078
NCBI_Iran; C185
RCB; RCB1934
TKG; TKG 0375
Chemistry resourcesChEMBL-Cells; CHEMBL3307500
ChEMBL-Targets; CHEMBL613978
PharmacoDB; HuT78_647_2019
PubChem_Cell_line; CVCL_0337
Encyclopedic resourcesWikidata; Q54896909
Experimental variables resourcesEFO; EFO_0002209

更多>>相关产品

总部地址:北京市怀柔区渤海镇怀沙路536号

关注我们
在线咨询
在线客服
电话咨询
微信客服
返回顶部