UT-7人类原巨核细胞型白血病细胞(STR鉴定正确)

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1258

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameUT-7
SynonymsUT7
AccessionBTCC-1258
Resource Identification InitiativeTo cite this cell line use: UT-7 (BTCC-1258)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Characteristics: CSF2 dependent.
Doubling time: ~36-48 hours (PubMed=1824823); ~70 hours (DSMZ=ACC-137).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; c.783_919del137; Zygosity=Unspecified (PubMed=1571549).
HLA typingSource: DSMZCellDive=ACC-137
Class I
HLA-AA*02:01:01,11:01:01
HLA-BB*55:02:01,55:02:01
HLA-CC*01:02:01,01:02:01
Class II
HLA-DPDPA1*01:03:01,02:02:02

DPB1*03:01:01,03:01:01
HLA-DRDRA*01:01:01,01:02:02

DRB1*08:02:01,08:02:01
Genome ancestrySource: PubMed=30894373

Origin% genome


African2.07
Native American0
East Asian, North82.57
East Asian, South12
South Asian0
European, North0
European, South3.36
DiseaseAdult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:


CVCL_5202 (UT-7/Epo)CVCL_5203 (UT-7/GM)
Sex of cellMale
Age at sampling64Y
CategoryCancer cell line
STR profileSource(s): CCRID; DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,23
D3S135816
D5S81812
D7S8208
D8S117911,15
D13S3178
D16S53910,12
D18S5114,17
D19S43314,14.2 (CCRID)
14,15 (DSMZ)
D21S1131.2
FGA23
Penta D9,11
Penta E16,17
TH016,9
TPOX10
vWA14,18 (DSMZ; PubMed=25877200)
14,18,19 (CCRID)

Run an STR similarity search on this cell line
Web pageshttp://www.cells-talk.com/index.php/page/copelibrary?key=UT-7
Publications

PubMed=2217443
Miura Y., Komatsu N., Suda T.
Growth and differentiation of two human megakaryoblastic cell lines CMK and UT-7.
Prog. Clin. Biol. Res. 356:259-270(1990)

PubMed=1824823
Komatsu N., Nakauchi H., Miwa A., Ishihara T., Eguchi M., Moroi M., Okada M., Sato Y., Wada H., Yawata Y., Suda T., Miura Y.
Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.
Cancer Res. 51:341-348(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=7647001; DOI=10.1111/j.1365-2141.1995.tb05591.x
Ito E., Kasai M., Hayashi Y., Toki T., Arai K., Yokoyama S., Kato K., Tachibana N., Yamamoto M., Yokoyama M.
Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome.
Br. J. Haematol. 90:607-614(1995)

PubMed=9096695; DOI=10.1038/sj.leu.2400621
Drexler H.G., Zaborski M., Quentmeier H.
Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.
Leukemia 11:541-551(1997)

PubMed=9195772
Tohyama K.
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000),255-262.
Leuk. Res. 25:275-278(2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K.-I., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0009490
CLDB; cl5398
CCRID; 1101HUM-PUMC000120
Cell_Model_Passport; SIDM01908
DepMap; ACH-001230
DSMZCellDive; ACC-137
Lonza; 41
Anatomy/cell type resourcesBTO; BTO:0000960
Biological sample resourcesBioSample; SAMN03472875
BioSample; SAMN10988426
Cell line collections (Providers)DSMZ; ACC-137
Chemistry resourcesChEMBL-Cells; CHEMBL3307293
ChEMBL-Targets; CHEMBL614057
PharmacoDB; UT7_1649_2019
PubChem_Cell_line; CVCL_2233
Encyclopedic resourcesWikidata; Q54992037

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