KG-1A人急性骨髓白血病细胞

价 格:¥2400

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1287

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameKG-1a
SynonymsKG-1A; KG1A; KG1a
AccessionBTCC-1287
Resource Identification InitiativeTo cite this cell line use: KG-1a (BTCC-1287)
CommentsPopulation: Caucasian.
Characteristics: Less differentiated subline of KG-1, composed of undifferentiated promyeloblasts.
Doubling time: ~45 hours (CLS=300234); ~50 hours (DSMZ=ACC-421).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 3688; FGFR1 + HGNC; 23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
DiseaseAdult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0374 (KG-1)
Sex of cellMale
Age at sampling59Y
CategoryCancer cell line
STR profileSource(s): ATCC; CCRID; CLS; COG; DSMZ; PubMed=11416159; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO7
D2S133820,23
D3S135815,16
D5S81813
D7S8208,10
D8S117913,14 (CCRID; CLS; DSMZ; PubMed=11416159; PubMed=25877200)
14 (COG)
D13S31711,12
D16S53910,11
D18S5110.2,18
D19S43311,16.2 (COG)
11,17 (DSMZ)
16.2 (PubMed=25877200)
D21S1128,29
FGA22
Penta D8,9
Penta E7,13
TH017,8
TPOX7 (PubMed=25877200)
7,9 (ATCC; CCRID; CLS; COG; DSMZ; ECACC; RCB; TKG)
vWA14,19

Run an STR similarity search on this cell line
Web pageshttp://www.cells-talk.com/index.php/page/copelibrary?key=KG-1
https://www.atcc.org/en/support/technical-support/faqs/description-of-normal-growth-and-morphology-of-atcc-ccl-246-1
Publications

PubMed=6967340; DOI=10.1182/blood.V56.2.265.265
Koeffler H.P., Billing R.J., Lusis A.J., Sparkes R.S., Golde D.W.
An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).
Blood 56:265-273(1980)

PubMed=3094604; DOI=10.1182/blood.V68.5.1101.1101
Furley A.J.W., Reeves B.R., Mizutani S., Altass L.J., Watt S.M., Jacob M.C., van den Elsen P., Terhorst C., Greaves M.F.
Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.
Blood 68:1101-1107(1986)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=22844360; DOI=10.3892/ol.2012.709
Pelliccia F., Ubertini V., Bosco N.
The importance of molecular cytogenetic analysis prior to using cell lines in research: the case of the KG-1a leukemia cell line.
Oncol. Lett. 4:237-240(2012)

Cross-references
Cell line databases/resourcesCLO; CLO_0007095
CLO; CLO_0051561
CLDB; cl3026
CLDB; cl3027
CCRID; 1102HUM-NIFDC00028
DSMZCellDive; ACC-421
LINCS_LDP; LCL-1057
Lonza; 835
Anatomy/cell type resourcesBTO; BTO:0005076
Biological sample resourcesBioSample; SAMN01821644
BioSample; SAMN03470993
Cell line collections (Providers)ATCC; CCL-246.1
BCRC; 60224
CLS; 300234
DSMZ; ACC-421
ECACC; 91030101
IZSLER; BS TCL 196
NCBI_Iran; C520
RCB; RCB1928
TKG; TKG 0402
Chemistry resourcesChEMBL-Cells; CHEMBL4295408
ChEMBL-Targets; CHEMBL4296453
PubChem_Cell_line; CVCL_1824
Encyclopedic resourcesWikidata; Q54899835

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