HET-1A人食管上皮细胞

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1288

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameHET-1A
SynonymsHet-1A; HET1A; Het1A
AccessionBTCC-1288
Resource Identification InitiativeTo cite this cell line use: HET-1A (BTCC-1288)
CommentsGroup: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10209.
Population: African American.
Doubling time: 27.4 +- 3.6 hours (PubMed=21127259).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [pRSV-T].
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: Indicated as originating from a 25 year old male in ATCC, but said to be derived from autopsy specimen from a 74 year old male.
Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
Cell type: Epithelial cell; CL=CL_0000066.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:

CVCL_4T84 (HET1AR)
Sex of cellMale
Age at sampling74Y
CategoryTransformed cell line
STR profileSource(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,12
D7S8209
D13S31711
D16S5399,11
TH017
TPOX11
vWA16

Run an STR similarity search on this cell line
Publications

CLPUB00265
Stoner G.D., Kaighn M.E., Resau J.H., Naito Z., Bowman D., Harris C.C.
Immortalized human esophageal epithelial cell lines for studies of carcinogen-induced cell transformation.
In Vitro Cell. Dev. Biol. 26:23A-23A(1990)

DOI=10.1007/978-1-4612-0411-4_30
Stoner G.D., Light B.A., Harris C.C.
Immortalization and oncogene transformation of human esophageal epithelial cells.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.297-305; Humana Press; New York (1990)

Patent=WO1991005062A1
Stoner G.D., Reddel R.R., Harris C.C.
Human esophageal epithelial cell lines.
Patent number WO1991005062A1, 18-Apr-1991

PubMed=1703038
Stoner G.D., Kaighn M.E., Reddel R.R., Resau J.H., Bowman D., Naito Z., Matsukura N., You M., Galati A.J., Harris C.C.
Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells.
Cancer Res. 51:365-371(1991)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=10078940; DOI=10.1002/(SICI)1098-2744(199902)24:2<128::aid-mc7>3.0.co;2-f
Compton K.R., Orringer M.B., Beer D.G.
Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines.
Mol. Carcinog. 24:128-136(1999)

PubMed=20139130; DOI=10.1093/carcin/bgq036
Duggan S.P., Behan F.M., Kirca M., Smith S.M., Reynolds J.V., Long A., Kelleher D.P.
An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.
Carcinogenesis 31:936-945(2010)

PubMed=20843300; DOI=10.1042/BC20100071
Underwood T.J., Derouet M.F., White M.J., Noble F., Moutasim K.A., Smith E., Drew P.A., Thomas G.J., Primrose J.N., Blaydes J.P.
A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.
Biol. Cell 102:635-644(2010)

PubMed=21127259; DOI=10.1152/ajpgi.00461.2010
Goldman A., Chen H.D.R., Roesly H.B., Hill K.A., Tome M.E., Dvorak B., Bernstein H., Dvorak K.
Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis.
Am. J. Physiol. Gastrointest. Liver Physiol. 300:G292-G302(2011)

DOI=10.1155/2014/376541
Akagi I., Ishibashi O., Matsutani T., Hagiwara N., Matsuda A., Nomura T., Makino H., Yoshida H., Miyashita M., Uchida E.
Comprehensive analysis of microRNA and mRNA expression in normal and tumorous human esophageal squamous cell lines using microarray datasets.
Dataset Papers Sci. 2013:376541.1-376541.3(2013)

PubMed=28224081; DOI=10.1016/j.gdata.2017.02.002
Akagi I., Ishibashi O.
RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.
Genomics Data 12:4-6(2017)

Cross-references
Cell line databases/resourcesCLO; CLO_0003718
Anatomy/cell type resourcesBTO; BTO:0004433
Biological sample resourcesBioSample; SAMN03471766
Cell line collections (Providers)ATCC; CRL-2692
Chemistry resourcesChEMBL-Cells; CHEMBL4295465
ChEMBL-Targets; CHEMBL4296426
PubChem_Cell_line; CVCL_3702
Encyclopedic resourcesWikidata; Q54882925

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