| Cell line name | HT-29-MTX-E12 |
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| Synonyms | HT29-MTX-E12; MTX-E12 |
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| Accession | BTCC-1342 |
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| Resource Identification Initiative | To cite this cell line use: HT-29-MTX-E12 (BTCC-1342) |
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| Comments | Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations | - Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
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| Disease | Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
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| Hierarchy | Parent: CVCL_6834 (HT-29-MTX) |
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| Sex of cell | Female |
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| Age at sampling | 44Y |
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| Category | Cancer cell line |
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| STR profile | Source(s): ECACC
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=11587485; DOI=10.1023/A:1010974909998
Behrens I., Stenberg P., Artursson P., Kissel T.
Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells.
Pharm. Res. 18:1138-1145(2001) |
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| Cross-references |
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| Cell line collections (Providers) | ECACC; 12040401 |
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| Encyclopedic resources | Wikidata; Q54896519 |
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