SW982人滑膜肉瘤细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1344

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameSW982
SynonymsSW-982; SW 982
AccessionBTCC-1344
Resource Identification InitiativeTo cite this cell line use: SW982 (BTCC-1344)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; USA.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: Stated to originate from a patient with a biphasic synovial sarcoma, however does not contain the SST-SSX1/SSX2 translocation which is typical of synovial sarcoma.
Derived from site: In situ; Synovium; UBERON=UBERON_0007616.
Sequence variations
  • Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (PubMed=20215515).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
HLA typingSource: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*07:02,49:01
HLA-CC*07:01,07:01
Genome ancestrySource: PubMed=30894373

Origin% genome


African0
Native American0.11
East Asian, North0
East Asian, South0
South Asian2.82
European, North67.54
European, South29.52
DiseaseBiphasic synovial sarcoma (NCIt: C4279)
Synovial sarcoma (ORDO: Orphanet_3273)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellFemale
Age at sampling25Y
CategoryCancer cell line
STR profileSource(s): ATCC; CLS; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D3S135815
D5S81811,13 (ATCC; CLS; Cosmic-CLP)
13 (PubMed=25877200)
D7S8209,11
D8S117911,14
D13S3178,12,13 (CLS)
12,13 (ATCC; Cosmic-CLP; PubMed=25877200)
D16S53911,12
D18S5116,18
D21S1128,30
FGA21,24
Penta D10,13
Penta E13,15
TH019.3
TPOX9,11
vWA19,20

Run an STR similarity search on this cell line
Web pageshttps://tcpaportal.org/mclp/
Publications

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

DOI=10.1007/978-94-011-3550-4_4
Hay R.J.
Development, availability and characterization of ATCC human and animal cell lines.
(In) Animal cell culture and production of biologicals; Sasaki R., Ikura K. (eds.); pp.27-39; Springer; Dordrecht (1991)

PubMed=15038780; DOI=10.1290/1543-706X(2003)039<0337:pcoahs>2.0.CO;2
Yamazaki T., Yokoyama T., Akatsu H., Tukiyama T., Tokiwa T.
Phenotypic characterization of a human synovial sarcoma cell line, SW982, and its response to dexamethasone.
In Vitro Cell. Dev. Biol. Anim. 39:337-339(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0009206
CCRID; 3101HUMTCHu209
Cell_Model_Passport; SIDM01161
Cosmic-CLP; 909759
DepMap; ACH-001274
IGRhCellID; SW982
LINCS_LDP; LCL-1880
Anatomy/cell type resourcesBTO; BTO:0006386
Biological sample resourcesBioSample; SAMN03471376
BioSample; SAMN03472764
Cell line collections (Providers)ATCC; HTB-93
BCRC; 60535
CLS; 300404
Chemistry resourcesChEMBL-Cells; CHEMBL3308534
ChEMBL-Targets; CHEMBL2366238
GDSC; 909759
PharmacoDB; SW982_1552_2019
PubChem_Cell_line; CVCL_1734
Encyclopedic resourcesWikidata; Q54971230
Experimental variables resourcesEFO; EFO_0002378

更多>>相关产品

总部地址:北京市怀柔区渤海镇怀沙路536号

关注我们
在线咨询
在线客服
电话咨询
微信客服
返回顶部