DMS153人小细胞肺癌细胞

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1359

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameDMS 153
SynonymsDMS-153; DMS153; Darmouth Medical School 153
AccessionBTCC-1359
Resource Identification InitiativeTo cite this cell line use: DMS 153 (BTCC-1359)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 28 days (PubMed=6266631); 5.8 days (PubMed=2986244).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr155Pro (c.463A>C); Zygosity=Homozygous (PubMed=14660794; DepMap).
Genome ancestrySource: PubMed=30894373

Origin% genome


African0.64
Native American0.56
East Asian, North3.7
East Asian, South0
South Asian0
European, North51.44
European, South43.66
DiseaseLung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individualCVCL_Z033 ! DMS 154
Sex of cellMale
Age at sampling44Y
CategoryCancer cell line
STR profileSource(s): ATCC; CCRID; ECACC; PubMed=25877200

Markers:
AmelogeninX (ATCC; CCRID)
X,Y (ECACC; PubMed=25877200)
CSF1PO10
D2S133817,20
D3S135814,17 (PubMed=25877200)
17 (CCRID)
D5S81812
D6S104311,18
D7S8208,10
D8S117912,14
D13S31712,13 (PubMed=25877200)
13 (ATCC; CCRID; ECACC)
D16S53912,13
D18S5116,17
D21S1126.2,30
FGA21
Penta D9,12
Penta E12 (CCRID)
12,13 (PubMed=25877200)
TH017,9.3
TPOX11
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::aid-cncr2820450513>3.0.CO;2-H
Pettengill O.S., Sorenson G.D., Wurster-Hill D.H., Curphey T.J., Noll W.W., Cate C.C., Maurer L.H.
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.
Cancer 45:906-918(1980)

PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5
Vindelov L.L., Hansen H.H., Spang-Thomsen M.
Growth characteristics and heterogeneity of small cell carcinoma of the lung.
Recent Results Cancer Res. 97:47-54(1985)

PubMed=9744504; DOI=10.1038/bjc.1998.553
Damstrup L., Rude Voldborg B., Spang-Thomsen M., Brunner N., Skovgaard Poulsen H.
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Br. J. Cancer 78:631-640(1998)

PubMed=12712436; DOI=10.1002/ijc.11106
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Int. J. Cancer 105:472-479(2003)

PubMed=14660794; DOI=10.1073/pnas.2536558100
Kanashiro C.A., Schally A.V., Groot K., Armatis P., Bernardino A.L.F., Varga J.L.
Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.
Proc. Natl. Acad. Sci. U.S.A. 100:15836-15841(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0002796
CLDB; cl1078
CCRID; 1101HUM-PUMC000397
CCRID; 4201HUM-CCTCC00167
Cell_Model_Passport; SIDM01504
DepMap; ACH-000594
IGRhCellID; DMS153
LINCS_LDP; LCL-1831
Biological sample resourcesBioSample; SAMN03471428
BioSample; SAMN03472954
BioSample; SAMN10988118
Cell line collections (Providers)ATCC; CRL-2064
CCTCC; GDC0167
ECACC; 95062827
Chemistry resourcesChEMBL-Cells; CHEMBL3308260
ChEMBL-Targets; CHEMBL2366167
GDSC; 687984
PharmacoDB; DMS153_298_2019
PubChem_Cell_line; CVCL_1175
Encyclopedic resourcesWikidata; Q54831295
Experimental variables resourcesEFO; EFO_0002163

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