NT2-D1(NTERA-2 clone D1)人睾丸癌细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1367

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameNT2-D1
SynonymsNT2/D1; NT2D1; Nt2D1; NTERA-2 clone D1; NTERA2-cloneD1; NTERA-2 cl.D1; NTera2 cl.D1; NTERA-2cl.D1; NTera 2/cl.D1; NTERA2CLD1; NTERA-2/D1; NTera2/D1; NTERA2-D1; NTera-2D1; Ntera2/D1; NTERA2/D1; NTERA2D1; NTera2D1; Tera
AccessionBTCC-1367
Resource Identification InitiativeTo cite this cell line use: NT2-D1 (BTCC-1367)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: NTERA-S-cl-D1; ArrayExpress=E-MTAB-783; Cosmic=1995598.
Misspelling: NTL-D1; Cosmic=2077191.
Misspelling: NT2101; Cosmic=2163756; PubMed=24812411.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Genome ancestrySource: PubMed=30894373

Origin% genome


African1.78
Native American0
East Asian, North0.45
East Asian, South1.42
South Asian4.09
European, North53.03
European, South39.23
DiseaseEmbryonal carcinoma (NCIt: C3752)
Embryonal carcinoma (ORDO: Orphanet_180226)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0034 (NTERA-2)
Children:


CVCL_7929 (NT2-N)CVCL_A5AF (Tera-CP)
Sex of cellMale
Age at sampling22Y
CategoryCancer cell line
STR profileSource(s): ATCC; Cosmic-CLP; ECACC

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8189,12
D7S82010,12
D13S31713
D16S53911,12,13
TH019.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pageshttps://en.wikipedia.org/wiki/NTERA-2
http://genome.ucsc.edu/ENCODE/protocols/cell/human/NT2-D1_protocol.pdf
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-113.html
Publications

PubMed=6144603; DOI=10.1016/0012-1606(84)90316-6
Andrews P.W.
Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
Dev. Biol. 103:285-293(1984)

PubMed=6694356
Andrews P.W., Damjanov I., Simon D., Banting G.S., Carlin C.R., Dracopoli N.C., Fogh J.
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
Lab. Invest. 50:147-162(1984)

PubMed=3293662; DOI=10.1016/0304-419X(88)90003-0
Andrews P.W.
Human teratocarcinomas.
Biochim. Biophys. Acta 948:17-36(1988)

PubMed=8242627
Timmer-Bosscha H., Timmer A., Meijer C., de Vries E.G.E., de Jong B., Oosterhuis J.W., Mulder N.H.
cis-diamminedichloroplatinum(ii) resistance in vitro and in vivo in human embryonal carcinoma cells.
Cancer Res. 53:5707-5713(1993)

PubMed=8411264; DOI=10.1002/jnr.490350603
Pleasure S.J., Lee V.M.-Y.
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
J. Neurosci. Res. 35:585-602(1993)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868
Feldman D.R., Iyer G., Van Alstine L., Patil S., Al-Ahmadie H., Reuter V.E., Bosl G.J., Chaganti R.S.K., Solit D.B.
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clin. Cancer Res. 20:3712-3720(2014)

PubMed=25802994; DOI=10.1177/026119291504300105
Jasnic-Savovic J., Klajn A., Milivojevic M., Mojsin M., Nikcevic G.
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation.
Altern. Lab. Anim. 43:9-18(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0008207
CLDB; cl3740
CLDB; cl5088
Cell_Model_Passport; SIDM01203
Cosmic-CLP; 908454
DepMap; ACH-002291
FCS-free; 172-2-320-1-3-3
LINCS_LDP; LCL-1901
Lonza; 1094
Anatomy/cell type resourcesBTO; BTO:0000946
Biological sample resourcesENCODE; ENCBS374ENC
ENCODE; ENCBS578HFO
ENCODE; ENCBS631LTU
ENCODE; ENCBS810EWQ
Cell line collections (Providers)ATCC; CRL-1973
BCRC; 60356
BCRJ; 0303
ECACC; 01071221
ICLC; HTL97025
IZSLER; BS TCL 204
Chemistry resourcesChEMBL-Cells; CHEMBL3307482
ChEMBL-Targets; CHEMBL614206
GDSC; 908454
PharmacoDB; NTERASclD1_1169_2019
PubChem_Cell_line; CVCL_3407
Encyclopedic resourcesWikidata; Q54931100
Experimental variables resourcesEFO; EFO_0005236

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