| Cell line name | 6T-CEM |
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| Synonyms | 6-T CEM |
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| Accession | BTCC-1368 |
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| Resource Identification Initiative | To cite this cell line use: 6T-CEM (BTCC-1368) |
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| Comments | Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8296.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations | - Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
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| Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
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| Hierarchy | Parent: CVCL_0207 (CCRF-CEM)
Children: |
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| Sex of cell | Female |
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| Age at sampling | 3Y11M |
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| Category | Cancer cell line |
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| STR profile | Source(s): ATCC; CCRID
Markers:| Amelogenin | X | | CSF1PO | 10,11 | | D2S1338 | 24 | | D3S1358 | 14,15 | | D5S818 | 11,12,13 (ATCC)
11,13 (CCRID) | | D7S820 | 9,14 | | D8S1179 | 13 | | D13S317 | 11,12 | | D16S539 | 10,13 | | D18S51 | 13,18 | | D19S433 | 14,15 | | D21S11 | 31,33.2 | | FGA | 23,24 | | TH01 | 6,7 | | TPOX | 8 | | vWA | 17,19 |
Run an STR similarity search on this cell line |
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| Publications | Patent=US4705687
Lau C.Y.
Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor.
Patent number US4705687, 10-Nov-1987 Patent=US4728614
Lau C.Y.
Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants.
Patent number US4728614, 01-Mar-1988 |
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| Cross-references |
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| Cell line databases/resources | CCRID; 3101HUMTCHu2 |
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| Biological sample resources | BioSample; SAMN03471201 |
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| Cell line collections (Providers) | ATCC; CRL-8296
CLS; 305132 |
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| Encyclopedic resources | Wikidata; Q54604612 |
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