NCI-H295R人肾上腺皮质腺癌细胞(STR鉴定正确)

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1374

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameNCI-H295R
SynonymsNCI H295R; NCIH295R; H295R; H-295R; H295R-S1
AccessionBTCC-1374
Resource Identification InitiativeTo cite this cell line use: NCI-H295R (BTCC-1374)
CommentsCharacteristics: Grows in a medium called Nu-Serum type I.
Doubling time: 25 hours (PubMed=29371329).
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
DiseaseAdrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyParent: CVCL_0456 (NCI-H295)
Children:



CVCL_5V09 (HAC13)CVCL_S898 (HAC15)CVCL_5V08 (HAC50)
Sex of cellFemale
Age at sampling48Y
CategoryCancer cell line
STR profileSource(s): ATCC; CCRID; CLS

Markers:
AmelogeninX
CSF1PO10,12
D2S133825
D3S135815,16
D5S81812
D7S8209,12
D8S117913
D13S31713
D16S53911
D18S5117
D19S43313
D21S1132.2
FGA19.2,24
Penta D8
Penta E5,12
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pageshttps://en.wikipedia.org/wiki/H295R
Publications

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
Rainey W.E., Saner K., Schimmer B.P.
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=18000308; DOI=10.1677/JOE-07-0166
Samandari E., Kempna P., Nuoffer J.-M., Hofer G., Mullis P.-E., Fluck C.E.
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.
J. Endocrinol. 195:459-472(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=23951072; DOI=10.1371/journal.pone.0071022
Nishi H., Arai H., Momiyama T.
NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca(2)(+)-mobilization/influx and cortisol secretion.
PLoS ONE 8:E71022-E71022(2013)

PubMed=29371329; DOI=10.1530/ERC-17-0447
Kiseljak-Vassiliades K., Zhang Y., Bagby S.M., Kar A., Pozdeyev N., Xu M., Gowan K., Sharma V., Raeburn C.D., Albuja-Cruz M.B., Jones K.L., Fishbein L., Schweppe R.E., Somerset H.L., Pitts T.M., Leong S., Wierman M.E.
Development of new preclinical models to advance adrenocortical carcinoma research.
Endocr. Relat. Cancer 25:437-451(2018)

PubMed=33981288; DOI=10.3389/fendo.2021.669426
Rossini E., Tamburello M., Abate A., Beretta S., Fragni M., Cominelli M., Cosentini D., Hantel C., Bono F., Grisanti S., Poliani P.L., Tiberio G.A.M., Memo M., Sigala S., Berruti A.
Cytotoxic effect of progesterone, tamoxifen and their combination in experimental cell models of human adrenocortical cancer.
Front. Endocrinol. 12:669426.1-669426.13(2021)

PubMed=34572026; DOI=10.3390/cells10092376
Wellman K., Fu R., Baldwin A., Rege J., Murphy E., Rainey W.E., Mukherjee N.
Transcriptomic response dynamics of human primary and immortalized adrenocortical cells to steroidogenic stimuli.
Cells 10:2376.1-2376.15(2021)

PubMed=35563746; DOI=10.3390/cells11091439
Sigala S., Bothou C., Penton D., Abate A., Peitzsch M., Cosentini D., Tiberio G.A.M., Bornstein S.R., Berruti A., Hantel C.
A comprehensive investigation of steroidogenic signaling in classical and new experimental cell models of adrenocortical carcinoma.
Cells 11:1439.1-1439.17(2022)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w
Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R., Hantel C.
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0008082
MCCL; MCC:0000355
CCRID; 1101HUM-PUMC000256
CCRID; 5301HUM-KCB15009YJ
IGRhCellID; NCIH295R
Lonza; 378
Anatomy/cell type resourcesBTO; BTO:0002588
Cell line collections (Providers)ATCC; CRL-2128
CLS; 300483
KCB; KCB 2015009YJ
Chemistry resourcesChEMBL-Cells; CHEMBL3307998
ChEMBL-Targets; CHEMBL612593
PubChem_Cell_line; CVCL_0458
Encyclopedic resourcesWikidata; Q25323725
Experimental variables resourcesEFO; EFO_0002289
Gene expression databasesArrayExpress; E-MTAB-38

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