4T1小鼠乳腺癌细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-2004

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line name4T1
Synonyms4T1-A; 4T1.0; 4T1/WT
AccessionBTCC-2004
Resource Identification InitiativeTo cite this cell line use: 4T1 (BTCC-2004)
CommentsCharacteristics: Metastatic.
Characteristics: Widely used model in cancer research due to its high similarity to human breast cancer. The tumor growth and metastatic spread of 4T1 cells closely mimic the behavior of human breast cancer. The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300).
Doubling time: 12.6 hours (ATCC=CRL-2539).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
DiseaseMalignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of originMus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
HierarchyParent: CVCL_W343 (410.4)
Children:



CVCL_QZ56 (4T1-eGFP-Puro)CVCL_QZ57 (4T1-Fluc-Neo)CVCL_QZ58 (4T1-Fluc-Neo/eGFP-Puro)
CVCL_QZ59 (4T1-Fluc-Neo/iRFP-Puro)CVCL_QZ60 (4T1-iRFP-Puro)CVCL_J239 (4T1-Luc)
CVCL_A4BM (4T1-Luc2 [ATCC])CVCL_L899 (4T1-luc2 [Caliper])CVCL_5J28 (4T1-luc2-GFP)
CVCL_5J46 (4T1-luc2-tdTomato)CVCL_QZ61 (4T1-mNIS (monoclonal))CVCL_QZ62 (4T1-mNIS-Neo/eGFP-Puro)
CVCL_QZ63 (4T1-mNIS-Neo/iRFP-Puro)CVCL_QZ64 (4T1-mNIS-Puro)CVCL_QZ65 (4T1-mNIS-Puro/Fluc-Neo)
CVCL_5I84 (4T1-Red-FLuc)CVCL_5I85 (4T1-Red-FLuc-GFP)CVCL_HE47 (4T1-S)
CVCL_5J45 (4T1-tdTomato)CVCL_GR31 (4T1.13)CVCL_GR32 (4T1.2)
CVCL_B3QZ (4T1.3)CVCL_JG34 (4T1/CMV-Luc #6)CVCL_C0U6 (4T1/EPB)
CVCL_XG69 (4T1/GFP/FlucII)

Sex of cellFemale
CategoryCancer cell line
STR profileSource(s): PubMed=31220119

Markers:
Mouse STR 1-115,16
Mouse STR 1-217
Mouse STR 2-116,17
Mouse STR 3-214,15
Mouse STR 4-221.3
Mouse STR 5-514
Mouse STR 6-418
Mouse STR 6-712
Mouse STR 7-125.2
Mouse STR 8-113
Mouse STR 11-218,19,20
Mouse STR 12-116
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-318,19
Mouse STR 19-213
Mouse STR X-125

Run an STR similarity search on this cell line
Web pageshttps://en.wikipedia.org/wiki/4T1
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/4/cell-lines-detail-66.html
Publications

PubMed=10411109; DOI=10.1023/A:1006689719505
Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E., Ho P., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L.
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)

PubMed=26857856; DOI=10.1007/s13577-015-0127-1
Abe H., Wada H., Baghdadi M., Nakanishi S., Usui Y., Tsuchikawa T., Shichinohe T., Hirano S., Seino K.-I.
Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S.
Hum. Cell 29:58-66(2016)

PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005
Sasaki S.-I., Baba T., Nishimura T., Hayakawa Y., Hashimoto S.-I., Gotoh N., Mukaida N.
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.
Cancer Lett. 378:23-32(2016)

PubMed=31220119; DOI=10.1371/journal.pone.0218412
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0001401
MCCL; MCC:0000017
CCRID; 3101MOUSCSP5056
CCRID; 3101MOUTCM32
CCRID; 4201MOU-CCTCC00294
CCRID; 6101MOU-CERC000107
Lonza; 481
Anatomy/cell type resourcesBTO; BTO:0004311
Biological sample resourcesBioSample; SAMN11397647
Cell line collections (Providers)AddexBio; C0006004/13
ATCC; CRL-2539
BCRJ; 0022
CCTCC; GDC0294
CLS; 300300
KCB; KCB 200967YJ
NCBI_Iran; C604
Chemistry resourcesChEMBL-Cells; CHEMBL3307995
ChEMBL-Targets; CHEMBL612589
PubChem_Cell_line; CVCL_0125
Encyclopedic resourcesWikidata; Q42802273
Experimental variables resourcesEFO; EFO_0002037

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