Cell line name | 4T1 | ||||||||||||||||||||||||||||||||||||
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Synonyms | 4T1-A; 4T1.0; 4T1/WT | ||||||||||||||||||||||||||||||||||||
Accession | BTCC-2004 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: 4T1 (BTCC-2004) | ||||||||||||||||||||||||||||||||||||
Comments | Characteristics: Metastatic. Characteristics: Widely used model in cancer research due to its high similarity to human breast cancer. The tumor growth and metastatic spread of 4T1 cells closely mimic the behavior of human breast cancer. The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300). Doubling time: 12.6 hours (ATCC=CRL-2539). Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG). Omics: Transcriptome analysis by microarray. Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911. | ||||||||||||||||||||||||||||||||||||
Disease | Malignant neoplasms of the mouse mammary gland (NCIt: C21678) | ||||||||||||||||||||||||||||||||||||
Species of origin | Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: BALB/cfC3H. | ||||||||||||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_W343 (410.4) Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): PubMed=31220119 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | https://en.wikipedia.org/wiki/4T1 https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/4/cell-lines-detail-66.html | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=10411109; DOI=10.1023/A:1006689719505 PubMed=26857856; DOI=10.1007/s13577-015-0127-1 PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005 PubMed=31220119; DOI=10.1371/journal.pone.0218412 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0001401 MCCL; MCC:0000017 CCRID; 3101MOUSCSP5056 CCRID; 3101MOUTCM32 CCRID; 4201MOU-CCTCC00294 CCRID; 6101MOU-CERC000107 Lonza; 481 | ||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO:0004311 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN11397647 | ||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | AddexBio; C0006004/13 ATCC; CRL-2539 BCRJ; 0022 CCTCC; GDC0294 CLS; 300300 KCB; KCB 200967YJ NCBI_Iran; C604 | ||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307995 ChEMBL-Targets; CHEMBL612589 PubChem_Cell_line; CVCL_0125 | ||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q42802273 | ||||||||||||||||||||||||||||||||||||
Experimental variables resources | EFO; EFO_0002037 |