HT22小鼠海马神经元细胞-BTCC典型培养物保藏中心-【BTCC细胞库】北京博沃尔斯生物科技有限公司官网

Cell line name

HT22

Synonyms

HT-22

Accession

BTCC-2018

Resource Identification Initiative

To cite this cell line use: HT22 (BTCC-2018)

Comments

Characteristics: Highly sensitive to glutamate and is therefore used to study glutamate-induced toxicity in neuronal cells.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA58].
Omics: Deep quantitative phosphoproteome analysis.
Omics: Secretome proteome analysis.
Derived from site: In situ; Brain, hippocampus; UBERON=UBERON_0002421.
Cell type: Neuron; CL=CL_0000540.

Species of origin

Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Hierarchy

Parent: CVCL_U378 (HT4 [Mouse neurons])
Children:


CVCL_C0DX (HT-22 rho-0)	CVCL_C0NE (HT22 Klf13 KO)	CVCL_C0NF (HT22 Klf9 KO)
CVCL_C0UA (HT22 TR/TO-rKlf9 clone 2.1)	CVCL_C0UB (HT22 TR/TO-mKlf13)	CVCL_C0U8 (HT22-BLRP-hTRb/pSV40-BirAV5)
CVCL_C0U9 (HT22-FLBIO-rKLF9/SV40-BirAV5)	CVCL_C0U7 (HT22-pSV40-BirAV5)

Category

Transformed cell line

STR profile

Source(s): Millipore

Markers:

Mouse STR 1-1	10,11
Mouse STR 1-2	13,17
Mouse STR 2-1	9
Mouse STR 3-2	14,15
Mouse STR 4-2	18.3,19.3,20.3
Mouse STR 5-5	13,14,15
Mouse STR 6-4	15.3
Mouse STR 6-7	12
Mouse STR 7-1	29
Mouse STR 8-1	15
Mouse STR 11-2	15,17,18
Mouse STR 12-1	20
Mouse STR 13-1	16.2
Mouse STR 15-3	20.3
Mouse STR 17-2	12,13,14
Mouse STR 18-3	17,19
Mouse STR 19-2	11,12
Mouse STR X-1	25

Web pages

http://salkinnovations.testtechnologypublisher.com/technology/7060
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-569.html

Publications

PubMed=7953717; DOI=10.1016/0006-8993(94)90334-4
Davis J.B., Maher P.
Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.
Brain Res. 652:169-173(1994)

PubMed=9292733; DOI=10.1016/S0896-6273(00)80953-8
Li Y., Maher P., Schubert D.
A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.
Neuron 19:453-463(1997)

PubMed=19135458; DOI=10.1016/j.lfs.2008.12.008
Liu J., Li L., Suo W.Z.
HT22 hippocampal neuronal cell line possesses functional cholinergic properties.
Life Sci. 84:267-271(2009)

PubMed=26227174; DOI=10.1002/pmic.201400623
Woo J.-M., Han D.-H., Park J.-H., Kim S.-J., Kim Y.-S.
In-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation.
Proteomics 15:3617-3622(2015)

PubMed=33430126; DOI=10.3390/nu13010179
Erber L.N., Luo A., Gong Y., Beeson M., Tu M., Tran P.V., Chen Y.
Iron deficiency reprograms phosphorylation signaling and reduces O-GlcNAc pathways in neuronal cells.
Nutrients 13:179.1-179.19(2021)

Cross-references

Cell line databases/resources

MCCL; MCC:0000214
Lonza; 248

Anatomy/cell type resources

BTO; BTO:0003037

Cell line collections (Providers)

CLS; 305158
Millipore; SCC129

Chemistry resources

ChEMBL-Cells; CHEMBL3307590
ChEMBL-Targets; CHEMBL614316
PubChem_Cell_line; CVCL_0321

Encyclopedic resources

Wikidata; Q54896579

Proteomic databases

PRIDE; PXD001597
PRIDE; PXD023294

质检报告（COA）
Markers:

Mouse STR 1-1	10,11
Mouse STR 1-2	13,17
Mouse STR 2-1	9
Mouse STR 3-2	14,15
Mouse STR 4-2	18.3,19.3,20.3
Mouse STR 5-5	13,14,15
Mouse STR 6-4	15.3
Mouse STR 6-7	12
Mouse STR 7-1	29
Mouse STR 8-1	15
Mouse STR 11-2	15,17,18
Mouse STR 12-1	20
Mouse STR 13-1	16.2
Mouse STR 15-3	20.3
Mouse STR 17-2	12,13,14
Mouse STR 18-3	17,19
Mouse STR 19-2	11,12
Mouse STR X-1	25

HT22小鼠海马神经元细胞

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