ARPE-19人视网膜色素上皮细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1018

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameARPE-19
SynonymsARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200
AccessionBTCC-1018
Resource Identification InitiativeTo cite this cell line use: ARPE-19 (BTCC-1018)
CommentsDoubling time: 55 hours (Note=From cell counting), 65 hours (Note=From absorbance) (DOI=10.5897/IJBMBR2013.0154).
Omics: Deep proteome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Metabolome analysis.
Omics: Transcriptome analysis by microarray.
Anecdotal: The number 19 in the cell line name is due to the fact that this cell line was established from a 19-year-old male who died from head trauma in a motor vehicle accident.
Misspelling: APRE-19; Note=Occasionally.
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_IQ60 (ARPE-19/CNTF)CVCL_IQ61 (ARPE-19/EGFP)CVCL_IQ62 (ARPE-19/GDNF)
CVCL_6338 (ARPE-19/HPV-16)CVCL_YP10 (LEPI)CVCL_DF66 (NGC-0295)
CVCL_DF67 (NGC-0301)CVCL_DF68 (NGC-0363)CVCL_DF65 (NGC0211)
Sex of cellMale
Age at sampling19Y
CategorySpontaneously immortalized cell line
STR profileSource(s): ATCC; PubMed=27499609; PubMed=31412689

Markers:
AmelogeninX,Y
CSF1PO11
D2S133819
D3S135814,15
D5S81813
D6S104317,19
D7S8209,11
D8S117913
D12S39121,22
D13S31711,12
D16S5399,11
D18S5112,16
D19S43312,13
D21S1128,29
FGA23
Penta D11,13
Penta E7,11
TH016,9.3
TPOX9,11
vWA16,19

Run an STR similarity search on this cell line
Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/a/cell-lines-detail-617.html
Publications

PubMed=8698076; DOI=10.1006/exer.1996.0020
Dunn K.C., Aotaki-Keen A.E., Putkey F.R., Hjelmeland L.M.
ARPE-19, a human retinal pigment epithelial cell line with differentiated properties.
Exp. Eye Res. 62:155-169(1996)

PubMed=11504951; DOI=10.1073/pnas.171266298
Lund R.D., Adamson P., Sauve Y., Keegan D.J., Girman S.V., Wang S., Winton H.L., Kanuga N., Kwan A.S.L., Beauchene L., Zerbib A., Hetherington L., Couraud P.-O., Coffey P., Greenwood J.
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.
Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001)

PubMed=14551534
Rogojina A.T., Orr W.E., Song B.K., Geisert E.E. Jr.
Comparing the use of Affymetrix to spotted oligonucleotide microarrays using two retinal pigment epithelium cell lines.
Mol. Vis. 9:482-496(2003)

PubMed=16262907; DOI=10.1186/1471-2415-5-25
Sharma R.K., Orr W.E., Schmitt A.D., Johnson D.A.
A functional profile of gene expression in ARPE-19 cells.
BMC Ophthalmol. 5:25.1-25.10(2005)

PubMed=21697133; DOI=10.1167/iovs.11-7479
Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

DOI=10.5897/IJBMBR2013.0154
Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A., Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.
Cell growth curves for different cell lines and their relationship with biological activities.
Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013)

PubMed=24251032; DOI=10.1155/2013/216359
Pasovic L., Utheim T.P., Maria R., Lyberg T., Messelt E.B., Aabel P., Chen D.F., Chen X., Eidet J.R.
Optimization of storage temperature for cultured ARPE-19 cells.
J. Ophthalmol. 2013:216359.1-216359.11(2013)

PubMed=25177495; DOI=10.1155/2014/801787
Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787.1-801787.18(2014)

PubMed=27499609
Wang Y., Sang A.-M., Zhu M.-H., Zhang G.-W., Guan H.-J., Ji M., Chen H.
Tissue factor induces VEGF expression via activation of the Wnt/beta-catenin signaling pathway in ARPE-19 cells.
Mol. Vis. 22:886-897(2016)

PubMed=28978645; DOI=10.1074/jbc.M117.812677
Chiang C.-K., Tworak A., Kevany B.M., Xu B., Mayne J., Ning Z.-B., Figeys D., Palczewski K.
Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.
J. Biol. Chem. 292:19826-19839(2017)

PubMed=29476476; DOI=10.1007/978-1-4939-7680-5_17
Fasler-Kan E., Aliu N., Wunderlich K., Ketterer S., Ruggiero S., Berger S., Meyer P.
The retinal pigment epithelial cell line (ARPE-19) displays mosaic structural chromosomal aberrations.
Methods Mol. Biol. 1745:305-314(2018)

PubMed=30167441; DOI=10.1016/j.dib.2018.06.103
Koirala D., Beranova-Giorgianni S., Giorgianni F.
Data-independent proteome analysis of ARPE-19 cells.
Data Brief 20:333-336(2018)

PubMed=31254428; DOI=10.1111/ceo.13578
Churm R., Dunseath G.J., Prior S.L., Thomas R.L., Banerjee S., Owens D.R.
Development and characterization of an in vitro system of the human retina using cultured cell lines.
Clin. Exp. Ophthalmol. 47:1055-1062(2019)

PubMed=31412689; DOI=10.3390/pharmaceutics11080412
Hellinen L., Pirskanen L., Tengvall-Unadike U., Urtti A., Reinisalo M.
Retinal pigment epithelial cell line with fast differentiation and improved barrier properties.
Pharmaceutics 11:412.1-412.12(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0001749
MCCL; MCC:0000038
CCRID; 3101HUMGNHu45
CCRID; 4201HUM-CCTCC00323
Lonza; 871
Anatomy/cell type resourcesBTO; BTO:0002335
Biological sample resourcesBioSample; SAMN03471862
ENCODE; ENCBS054LTE
ENCODE; ENCBS534TJM
Cell line collections (Providers)ATCC; CRL-2302
BCRC; 60383
BCRJ; 0041
CCTCC; GDC0323
CLS; 305025
IZSLER; BS CL 193
Chemistry resourcesChEMBL-Cells; CHEMBL4295388
ChEMBL-Targets; CHEMBL4296399
PubChem_Cell_line; CVCL_0145
Encyclopedic resourcesWikidata; Q28812659
Experimental variables resourcesEFO; EFO_0006271
Gene expression databasesGEO; GSM1227434
Metabolomic databasesMetaboLights; MTBLS213
Proteomic databasesPRIDE; PXD006125
PRIDE; PXD006269
PRIDE; PXD009607
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number31

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