C-33A人子宫颈癌细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1027

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameC-33 A
SynonymsC33A; C33a; C33-A; C-33-A; C-33A; C33
AccessionBTCC-1027
Resource Identification InitiativeTo cite this cell line use: C-33 A (BTCC-1027)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Population: Caucasian.
Doubling time: 1.36 days (PubMed=29156801).
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Secretome proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=1648218).
HLA typingSource: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*07:02,44:02
HLA-CC*05:01,07:02
Genome ancestrySource: PubMed=30894373

Origin% genome


African0.41
Native American0.33
East Asian, North0.48
East Asian, South0.19
South Asian0.82
European, North66.58
European, South31.19
DiseaseCervical squamous cell carcinoma, not otherwise specified (NCIt: C180839)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_4J71 (HOE6V)CVCL_X008 (SK-OV-4)CVCL_A457 (SK-OV-6)
Originate from same individualCVCL_1E27 ! C-33 B
Sex of cellFemale
Age at sampling66Y
CategoryCancer cell line
STR profileSource(s): AddexBio; ATCC; CCRID; Cosmic-CLP; DepMap; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133823,25
D3S135816
D5S81811,12
D7S82010
D8S117910,14
D13S31713
D16S53913,14
D18S5115,17,18 (DepMap)
15,18 (PubMed=25877200)
D19S43311,13,14
D21S1129,30,31
FGA21,26
Penta D10
Penta E6,8
TH017,8
TPOX9
vWA18,20

Run an STR similarity search on this cell line
Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-23.html
Publications

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2990217
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1648218; DOI=10.1073/pnas.88.13.5523
Scheffner M., Munger K., Byrne J.C., Howley P.M.
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 88:5523-5527(1991)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24134916; DOI=10.1186/1755-8166-6-44
McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.H.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44.1-44.23(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28261610; DOI=10.1155/2017/4180703
Kontostathi G., Zoidakis J., Makridakis M., Lygirou V., Mermelekas G., Papadopoulos T., Vougas K., Vlamis-Gardikas A., Drakakis P., Loutradis D., Vlahou A., Anagnou N.P., Pappa K.I.
Cervical cancer cell line secretome highlights the roles of transforming growth factor-beta-induced protein ig-h3, peroxiredoxin-2, and NRF2 on cervical carcinogenesis.
Biomed Res. Int. 2017:4180703.1-4180703.15(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0002115
CLDB; cl7126
CCRID; 1101HUM-PUMC000172
CCRID; 1102HUM-NIFDC00091
CCRID; 3101HUMTCHu176
CCRID; 4201HUM-CCTCC00144
Cell_Model_Passport; SIDM00889
Cosmic-CLP; 687505
DepMap; ACH-001333
IGRhCellID; C33A
LINCS_LDP; LCL-1300
Anatomy/cell type resourcesBTO; BTO:0001968
Biological sample resourcesBioSample; SAMN03473073
Cell line collections (Providers)AddexBio; C0008003/382
ATCC; HTB-31
ATCC; CRM-HTB-31
BCRC; 60554
BCRJ; 0348
CCTCC; GDC0144
CLS; 305072
ICLC; HTL02004
Chemistry resourcesChEMBL-Cells; CHEMBL3308230
ChEMBL-Targets; CHEMBL614370
ChEMBL-Targets; CHEMBL2366313
GDSC; 687505
PharmacoDB; C33A_150_2019
PubChem_Cell_line; CVCL_1094
Encyclopedic resourcesWikidata; Q54799738
Experimental variables resourcesEFO; EFO_0002120

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