C8166人T细胞性白血病细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1030

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameC8166
SynonymsC8166-CD4
AccessionBTCC-1030
Resource Identification InitiativeTo cite this cell line use: C8166 (BTCC-1030)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap).
Genome ancestrySource: PubMed=30894373

Origin% genome


African0.3
Native American0.05
East Asian, North1.72
East Asian, South0
South Asian0
European, North64.43
European, South33.5
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:



CVCL_0195 (C8166/45)CVCL_A6UT (C8166/CCR5)CVCL_1H07 (M8166)
Sex of cellMale
Age at sampling<1D
CategoryTransformed cell line
Web pageshttp://www.nibsc.org/Default.aspx?pageid=597&id=0013&theme=default
Publications

PubMed=6412453; DOI=10.1016/0042-6822(83)90395-1
Salahuddin S.Z., Markham P.D., Wong-Staal F., Franchini G., Kalyanaraman V.S., Gallo R.C.
Restricted expression of human T-cell leukemia/lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes.
Virology 129:51-64(1983)

PubMed=12920029; DOI=10.1182/blood-2003-04-1043
Chung H.-K., Young H.A., Goon P.K.C., Heidecker G., Princler G.L., Shimozato O., Taylor G.P., Bangham C.R.M., Derse D.D.
Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.
Blood 102:4130-4136(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resourcesCLO; CLO_0002149
CLDB; cl589
Cell_Model_Passport; SIDM00072
DepMap; ACH-000206
LINCS_LDP; LCL-1011
Biological sample resourcesBioSample; SAMN10989599
Cell line collections (Providers)ECACC; 88051601
KCB; KCB 94019YJ
Chemistry resourcesChEMBL-Cells; CHEMBL3307638
ChEMBL-Targets; CHEMBL614533
PharmacoDB; C8166_157_2019
PubChem_Cell_line; CVCL_1099
Encyclopedic resourcesWikidata; Q54808257
Gene expression databasesArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827337
GEO; GSM1669640
Polymorphism and mutation databasesCosmic; 906829
IARC_TP53; 21206
Progenetix; CVCL_1099
Sequence databasesEGA; EGAS00001000978

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