CaSki人宫颈癌肠转移细胞/人宫颈癌上皮细胞

价 格:¥1800

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1039

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameCa Ski
SynonymsCa-Ski; CaSki; Caski; CASKI
AccessionBTCC-1039
Resource Identification InitiativeTo cite this cell line use: Ca Ski (BTCC-1039)
CommentsGroup: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Virology: Contains from 100 to 800 copies of the HPV16 genome; some complete and others truncated.
Doubling time: 3.2 days (PubMed=29156801).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Small intestine; UBERON=UBERON_0002108.
Sequence variations
  • Mutation; HGNC; 7133; KMT2D; Simple; p.Gln4079Ter (c.12235C>T); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=9887230).
HLA typingSource: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*07:02,37:01
HLA-CC*07:02,07:02
Genome ancestrySource: PubMed=30894373

Origin% genome


African1.02
Native American0
East Asian, North1.86
East Asian, South0
South Asian0
European, North68.36
European, South28.76
DiseaseHuman papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellFemale
Age at sampling40Y
CategoryCancer cell line
STR profileSource(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DepMap; ECACC; JCRB; KCLB; PubMed=25877200; PubMed=29156801; RCB; TKG

Markers:
AmelogeninX
CSF1PO10
D2S133821
D3S135815
D5S81813
D7S8208,11
D8S117915
D13S3178,12
D16S53911,12
D18S5117
D19S43315,16
D21S1130
FGA21
Penta D10
Penta E5
TH017
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-21.html
Publications

PubMed=867042; DOI=10.1126/science.867042
Pattillo R.A., Hussa R.O., Story M.T., Ruckert A.C.F., Shalaby M.R., Mattingly R.F.
Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line.
Science 196:1456-1458(1977)

PubMed=2990217
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3029430; DOI=10.1128/JVI.61.4.962-971.1987
Baker C.C., Phelps W.C., Lindgren V., Braun M.J., Gonda M.A., Howley P.M.
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.
J. Virol. 61:962-971(1987)

PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7
Grenman S.E., Shapira A., Carey T.E.
In vitro response of cervical cancer cell lines CaSki, HeLa, and ME-180 to the antiestrogen tamoxifen.
Gynecol. Oncol. 30:228-238(1988)

PubMed=7751322; DOI=10.1007/BF01366967
Rantanen V., Grenman S.E., Kulmala J., Grenman R.
The intrinsic radiosensitivity and sublethal damage repair capacity of five cervical carcinoma cell lines tested with the 96-well-plate assay.
J. Cancer Res. Clin. Oncol. 121:230-234(1995)

CLPUB00481
Kuno H., Yoshida T.
Detection of human papillomavirus types 16, 18, and 33 in cell lines derived from human genital organs by polymerase chain reaction.
Res. Commun. Inst. Ferment. Osaka 18:6-12(1997)

PubMed=9887230; DOI=10.1006/gyno.1998.5194
Rantanen V., Grenman S.E., Kurvinen K., Hietanen S., Raitanen M., Syrjanen S.
p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.
Gynecol. Oncol. 71:352-358(1998)

PubMed=10423141; DOI=10.1099/0022-1317-80-7-1725
Meissner J.D.
Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.
J. Gen. Virol. 80:1725-1733(1999)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=17311676; DOI=10.1186/1471-2164-8-53
Kloth J.N., Oosting J., van Wezel T., Szuhai K., Knijnenburg J., Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
BMC Genomics 8:53.1-53.13(2007)

PubMed=17611311
Yang C., Li G.-C., Li Y.-H., Hu J.-Y., Xiao Y., Zhang Z.-J.
Biological properties of Caski cell lines induced by exposing to the space environment.
Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:380-386(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003
Schmitt M., Pawlita M.
The HPV transcriptome in HPV16 positive cell lines.
Mol. Cell. Probes 25:108-113(2011)

PubMed=24134916; DOI=10.1186/1755-8166-6-44
McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.H.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44.1-44.23(2013)

PubMed=24201445; DOI=10.1101/gr.164806.113
Akagi K., Li J.-F., Broutian T.R., Padilla-Nash H.M., Xiao W.-H., Jiang B., Rocco J.W., Teknos T.N., Kumar B., Wangsa D., He D., Ried T., Symer D.E., Gillison M.L.
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resourcesCLO; CLO_0002165
CLO; CLO_0002201
CLO; CLO_0050930
CLDB; cl603
CLDB; cl604
CLDB; cl605
CLDB; cl4940
CCRID; 1101HUM-PUMC000101
CCRID; 1102HUM-NIFDC00093
CCRID; 3101HUMTCHu137
CCRID; 4201HUM-CCTCC00111
Cell_Model_Passport; SIDM00923
Cosmic-CLP; 906824
DepMap; ACH-001336
IGRhCellID; CaSki%20GEO
LINCS_HMS; 50006
LINCS_LDP; LCL-1541
Lonza; 1669
Anatomy/cell type resourcesBTO; BTO:0003109
Biological sample resourcesBioSample; SAMN01821540
BioSample; SAMN01821672
BioSample; SAMN01821725
BioSample; SAMN03473214
Cell line collections (Providers)AddexBio; C0008004/375
ATCC; CRL-1550
ATCC; CRM-CRL-1550
ATCC; CRL-7915 - Discontinued
BCRC; 60251
CCTCC; GDC0111
CLS; 300145
ECACC; 87020501
IBRC; C10345
ICLC; HTL98018
IZSLER; BS TCL 201
JCRB; IFO50007
KCB; KCB 2013034YJ
KCLB; 21550
RCB; RCB1947
TKG; TKG 0366
Chemistry resourcesChEMBL-Cells; CHEMBL3308097
ChEMBL-Targets; CHEMBL1075403
GDSC; 906824
PharmacoDB; CaSki_158_2019
PubChem_Cell_line; CVCL_1100
Encyclopedic resourcesWikidata; Q54808287
Experimental variables resourcesEFO; EFO_0006549


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